PMID: 3760777Oct 1, 1986Paper

Aging and arteriosclerosis. I. Development of myointimal hyperplasia after endothelial injury

The Journal of Experimental Medicine
R J HaririM E Weksler

Abstract

Old Fischer 344 rats are more susceptible to vascular lesions after arterial endothelial injury than are young animals. Thus, 20-26-mo-old Fischer 344 rats developed greater and more persistent intimal proliferative lesions than did 2-5-mo-old rats after aortic endothelial denudation. 3 d after deendothelialization, intimal thickness was increased two-fold in both old and young animals. However, 14 d after endothelial injury, intimal thickness had increased nearly five times in old animals, but had regressed to normal in young animals. Intimal thickness of young aortic grafts transplanted into young recipients did not differ significantly from adjacent host aorta or autotransplanted aortic segments 6 wk after surgery. In contrast, intimal thickness of old grafts transplanted into young recipients was eight times greater than adjacent young host aorta 6 wk after surgery. The density of cell nuclei in the intima of old grafts was also much greater than that in young grafts. Thus, in two experimental models of vascular injury, old rats have consistently had greater myointimal hyperplasia than young rats. The increased proliferative response of aortic smooth muscle cells after vascular injury of old animals may contribute to the in...Continue Reading

References

Feb 20, 1986·The New England Journal of Medicine·R Ross
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M B StemermanR Gardner

❮ Previous
Next ❯

Citations

Feb 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·M BretonJ Picard
Jan 29, 2010·Heart and Vessels·Yoshiaki Maruyama
May 7, 2005·Pflügers Archiv : European journal of physiology·K M RiceE R Blough
Dec 16, 1994·Mechanisms of Ageing and Development·G D PhillipsD R Knighton
Sep 15, 2001·Mechanisms of Ageing and Development·L MiaoJ H Zhang
Dec 6, 2001·Diabetes Research and Clinical Practice·B P Yu, H Y Chung
May 19, 2000·Experimental Gerontology·M S Lundberg, M T Crow
Jul 4, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Edward G Lakatta, Steven J Sollott
May 14, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Fumiyoshi KasagiShoichiro Fujita
Oct 22, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sammy D D EghbaliehAlan Dardik
Jun 21, 2001·The American Journal of Geriatric Cardiology·Edward G. Lakatta
Jul 11, 2009·Vascular Health and Risk Management·Cezar S StaniloaeTejas Patel
Aug 1, 1996·Aging : Clinical and Experimental Research·C Bilato, M T Crow
Jan 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Claudio NapoliLouis J Ignarro
Jul 12, 2011·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Alexander SheehyIgor Polyakov
Apr 1, 2011·Journal of the American Medical Directors Association·Jennifer Gonik Chester, James L Rudolph
Dec 5, 2006·The Journal of Nutritional Biochemistry·Lucía Gómez-AmoresCarmen M Vázquez
Jan 1, 1993·International Journal of Cardiology·D BenchimolH Bricaud
Feb 21, 2006·Atherosclerosis·Augusto OrlandiLuigi Giusto Spagnoli
Oct 18, 2005·American Journal of Surgery·Fabio A KudoAlan Dardik
Feb 6, 2015·Current Atherosclerosis Reports·John F Wagener, Sunil V Rao
Jan 23, 2015·Journal of Aging Research·K M RiceE R Blough
Sep 1, 1990·Differentiation; Research in Biological Diversity·S T NikkariO Jaakkola
Jul 1, 1991·Differentiation; Research in Biological Diversity·A Hultgårdh-NilssonN R Ringertz
Dec 1, 2017·Journal of Cell Communication and Signaling·B A BrownS J George
Jul 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Daniele TorellaMassimo Chiariello
Oct 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M L Bochaton-PiallatG Gabbiani
Apr 22, 2010·Circulation. Cardiovascular Interventions·Ellen A DawsonDaniel J Green
Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Giuseppa GennaroAlain Rivard
Jun 5, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Gaia SpinettiEdward G Lakatta
Aug 9, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Hiroyuki HaoMarie-Luce Bochaton-Piallat

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.