PMID: 11911497Mar 26, 2002Paper

Aging and calcium buffering in adrenergic neurons

Autonomic Neuroscience : Basic & Clinical
William J PottorfJohn N Buchholz

Abstract

The aging process at the cellular, organ and whole organism levels is in many respects a mystery. A common bias among those who study aging is that cellular homeostasis "generally falls apart". The assumption of a general deterioration in cellular homeostasis does not take into account that many individuals age quite well maintaining even robust physiological and mental functions. One facet of aging studies that has come to the forefront is the impact of age on the control of the ion messenger, calcium. Emerging evidence suggests that despite age-related declines in any one component or multiple components of the calcium buffering systems, compensatory mechanisms may be able to maintain overall calcium homeostasis. This brief review focuses specifically on the ability of peripheral neurons to maintain control of the ion messenger calcium with advancing age. In addition, the idea that the impact of age on calcium homeostasis may be more subtle due to complex and integrated mechanisms that control this ion is discussed.

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Citations

May 12, 2009·Ageing Research Reviews·Monika Puzianowska-Kuznicka, Jacek Kuznicki
May 12, 2009·Neuroscience Research·Yasuto KashiyaeManabu Sakakibara
Jun 24, 2003·Journal of Applied Physiology·Greg G Geary, John N Buchholz

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