Aging and computational systems biology

Wiley Interdisciplinary Reviews. Systems Biology and Medicine
Kathleen M MooneyMark T Mc Auley

Abstract

Aging research is undergoing a paradigm shift, which has led to new and innovative methods of exploring this complex phenomenon. The systems biology approach endeavors to understand biological systems in a holistic manner, by taking account of intrinsic interactions, while also attempting to account for the impact of external inputs, such as diet. A key technique employed in systems biology is computational modeling, which involves mathematically describing and simulating the dynamics of biological systems. Although a large number of computational models have been developed in recent years, these models have focused on various discrete components of the aging process, and to date no model has succeeded in completely representing the full scope of aging. Combining existing models or developing new models may help to address this need and in so doing could help achieve an improved understanding of the intrinsic mechanisms which underpin aging.

References

May 31, 1990·Nature·C B HarleyC W Greider
Apr 1, 1972·Journal of the American Geriatrics Society·D Harman
Feb 19, 2000·Hematology/oncology Clinics of North America·R Yancik, L A Ries
Sep 6, 2000·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T TakahashiK Yonezawa
Jun 28, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R GredillaG Barja
Dec 26, 2001·Human Molecular Genetics·M EstellerJ G Herman
Feb 19, 2002·Oncogene·Kathleen Collins, James R Mitchell
May 22, 2002·Mechanisms of Ageing and Development·Zhiyong ZhangBruce Richardson
Aug 28, 2002·American Journal of Epidemiology·Joan LindsayIan McDowell
Jun 14, 2003·TheScientificWorldJournal·Leonid A Gavrilov, Natalia S Gavrilova
Jul 29, 2003·Aging Cell·Carole J Proctor, Thomas B L Kirkwood
Dec 9, 2003·Mechanisms of Ageing and Development·Liang LiuTrygve O Tollefsbol
Dec 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Arthur D Riggs, Zhenggang Xiong
Jan 16, 2004·Genes & Development·Su-Ju LinLeonard Guarente
Jan 28, 2004·Comptes rendus biologies·Charles AuffrayLeroy Hood
Jun 12, 2004·Biological Reviews of the Cambridge Philosophical Society·Gustavo Barja
Nov 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Blanka Rogina, Stephen L Helfand
Dec 22, 2004·Mechanisms of Ageing and Development·Carole J ProctorThomas B L Kirkwood
Apr 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kevin R ShortK Sreekumaran Nair
Apr 27, 2005·Journal of Bioinformatics and Computational Biology·Stephen RamseyHamid Bolouri
May 12, 2005·Mechanisms of Ageing and Development·Edward J Masoro
May 17, 2005·Mechanisms of Ageing and Development·David A Sinclair
Jan 7, 2006·Nature·Michael Springer, Johan Paulsson
Jul 19, 2006·The Journal of Biological Chemistry·Stefan M SchiekeToren Finkel
Oct 13, 2006·Bioinformatics·Stefan HoopsUrsula Kummer
Nov 3, 2006·Genes & Development·Marcia C Haigis, Leonard P Guarente
May 4, 2007·Archives of Biochemistry and Biophysics·Insil KimJohn J Lemasters
Oct 27, 2007·The Proceedings of the Nutrition Society·Geraldine J CuskellyIan S Young
Dec 7, 2007·Molecular Systems Biology·Huiling XueJing-Dong J Han
Dec 8, 2007·Bio Systems·R D PortugalB F Svaiter
Dec 18, 2007·Neoplasia : an International Journal for Oncology Research·Ana C E CamposMiriam G Jasiulionis

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Citations

Jul 28, 2016·Biochimica Et Biophysica Acta·Suchi SmitaRüdiger Köhling
Dec 23, 2016·Briefings in Bioinformatics·Mark T Mc AuleyJ Enrique Salcedo-Sora
Oct 13, 2017·Antioxidants & Redox Signaling·Mark A McCormick, Daniel E L Promislow
May 1, 2018·The Proceedings of the Nutrition Society·A E MorganM T Mc Auley
Jan 25, 2018·Sports Medicine·Candice ColbeyNicholas P West
Apr 5, 2018·Aging·Timothy E HoffmanWilliam H Hanneman
Apr 10, 2020·Royal Society Open Science·Yanli WangChing-Shin Chou
Oct 12, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Parya AghasafariRamana Pidaparti
Jan 18, 2017·Bioscience Reports·Mark T Mc AuleyCarole J Proctor
Nov 17, 2020·Frontiers in Molecular Biosciences·Timothy E HoffmanJulie A Moreno

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