Aging and dietary influences on plasma lipoproteins and apolipoproteins in nonhuman primates

Metabolism: Clinical and Experimental
K K WillcoxD D Williams

Abstract

Nineteen young (3 to 4-years-old), 25 adult (8 to 14-years-old), and 22 aged (18 years and older) pig-tailed macaques (Macaca nemestrina) were fed a semipurified control diet stringent in fat, cholesterol, refined sugar, and sodium for six months. Each group was almost equally divided by sex. Thereafter, half of each age group was fed a test diet high in fat (41% of calories), cholesterol (865 mg/kg), sodium, and refined sugar, while the rest consumed the control diet. After three years of dietary treatment, plasma and blood volumes were determined and fasting blood samples were collected for lipoprotein analysis. The protein content of very low density lipoproteins (VLDL) was increased in the test animals as compared to the controls. In general, low density lipoprotein (LDL) cholesterol, protein, and apolipoprotein B-100 values were markedly elevated by the test diet. However, these elevations were mainly confined to the young and adult groups, with little or no increases observed in the old group. The test diet also induced small but significant increases in high density lipoprotein (HDL) cholesterol, protein, and apolipoprotein A-I values. In addition, HDL cholesterol and protein values were higher in young females than male...Continue Reading

References

Apr 15, 1978·Lancet·D W Anderson
Nov 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J E GreenleafG R Mangseth
Jun 1, 1979·Metabolism: Clinical and Experimental·J A MorrisonC J Glueck
May 1, 1977·Age and Ageing·S G WebsterE Gowland
Dec 6, 1969·Lancet·M Eastwood
Aug 4, 1972·Nature·J Robertson
Mar 1, 1972·Preventive Medicine·W E Connor, S L Connor
Jan 1, 1971·Annals of Internal Medicine·W B KannelP M McNamara
Nov 1, 1981·The Journal of Clinical Investigation·R W MahleyK H Weisgraber
Nov 1, 1984·Scientific American·M S Brown, J L Goldstein
May 1, 1980·Proceedings of the Society for Experimental Biology and Medicine·M R McMahanG P Sackett
Feb 1, 1982·Journal of Chronic Diseases·R J HershcopfJ D Tobin
May 1, 1981·The American Journal of Clinical Nutrition·A G ErshowK C Hayes
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON
Jan 1, 1958·The American Journal of Medicine·R H FURMANE C KEATY
Mar 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·A KEYSJ T ANDERSON

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Citations

Mar 1, 1991·Biological Trace Element Research·S A Hing, K Y Lei
Sep 1, 1991·Aging : Clinical and Experimental Research·S Calandra, P Tarugi
Jul 1, 2000·Primates; Journal of Primatology·Akiko TakenakaOsamu Takenaka

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