PMID: 11911499Mar 26, 2002Paper

Aging and neuronal plasticity: lessons from a model

Autonomic Neuroscience : Basic & Clinical
K A Crutcher

Abstract

In spite of many well-documented examples of age-related reductions in neuronal plasticity, the causes of such changes remain largely unknown. One example of age-reduced plasticity involves an aberrant sprouting response of mature rat sympathetic neurons into the CNS (hippocampal formation). This phenomenon has proven to be useful for exploring the relative contribution of target aging (extrinsic influences) versus neuronal aging (intrinsic influences) to reduced sprouting. Aged sympathetic neurons mount a robust growth response when confronted with young target tissue or when exposed to exogenous trophic factor in vivo. In contrast, the aged target tissue (the hippocampal formation in this example) exhibits reduced receptivity for sympathetic sprouting. This change in the target does not appear to be due to alterations in baseline levels of trophic or substrate support for axonal growth. Rather, aging appears to dampen the consequences of target denervation so that the aged target elicits less sprouting. Age-related reductions in neuronal sprouting are speculated to reflect increasing commitment to information storage at the expense of neuronal plasticity.

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Citations

Aug 21, 2004·Journal of Neurotrauma·Young Seob GwakClaire E Hulsebosch
Jul 12, 2011·Psychiatry Research·Ludmyla KandrataviciusJoao Pereira Leite
May 24, 2008·Neurobiology of Aging·Uros KovacicFajko F Bajrović
Sep 6, 2005·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Karina Martinez GagliardoAntonio Augusto Coppi Maciel Ribeiro
Jun 4, 2020·European Journal of Pain : EJP·Fernanda ValerioDaniel Ciampi de Andrade

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