Aging and Parkinson's disease: Different sides of the same coin?

Movement Disorders : Official Journal of the Movement Disorder Society
Timothy J CollierJeffrey H Kordower

Abstract

Despite abundant epidemiological evidence in support of aging as the primary risk factor for PD, biological correlates of a connection have been elusive. In this article, we address the following question: does aging represent biology accurately characterized as pre-PD? We present evidence from our work on midbrain dopamine neurons of aging nonhuman primates that demonstrates that markers of known correlates of dopamine neuron degeneration in PD, including impaired proteasome/lysosome function, oxidative/nitrative damage, and inflammation, all increase with advancing age and are exaggerated in the ventral tier substantia nigra dopamine neurons most vulnerable to degeneration in PD. Our findings support the view that aging-related changes in the dopamine system approach the biological threshold for parkinsonism, actively producing a vulnerable pre-parkinsonian state. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

References

Oct 1, 1991·Brain : a Journal of Neurology·J M Fearnley, A J Lees
Feb 1, 1989·Journal of Neurochemistry·D T DexterC D Marsden
Dec 24, 1983·Lancet·D B Calne, J W Langston
Feb 1, 1984·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A Barbeau
Sep 1, 1982·Archives of Neurology·D M Mann, P O Yates
Dec 2, 1993·Nature·C KenyonR Tabtiang
Jan 11, 1996·The New England Journal of Medicine·D A BennettD A Evans
Sep 25, 1995·Brain Research·H PakkenbergB Pakkenberg
Dec 1, 1995·Acta Neurologica Scandinavica·M A HelyM A Adena
Aug 28, 1997·Nature·M G SpillantiniM Goedert
Jun 3, 1999·Brain Research·A H AndersenM J Avison
Mar 10, 2000·Brain Research·Z D LingP M Carvey
Oct 27, 2001·Archives of Neurology·J Jankovic, A S Kapadia
Dec 6, 2002·The American Journal of Pathology·Jian-Hui ZhuCharleen T Chu
Dec 31, 2002·Experimental Neurology·Kevin St P McNaughtC Warren Olanow
Apr 23, 2003·Archives of Neurology·Nico J DiederichChristopher G Goetz
Nov 1, 2003·Science·A B SingletonK Gwinn-Hardy
Mar 17, 2004·The Journal of Comparative Neurology·Alison L McCormackAnn Marie Janson
Sep 15, 2004·Cell and Tissue Research·A K Stark, B Pakkenberg
Sep 29, 2004·The Journal of Comparative Neurology·Tomás González-HernándezManuel Rodríguez
Jan 5, 2005·Experimental Neurology·Timothy J CollierJeffrey H Kordower
Dec 2, 2005·The Journal of Comparative Neurology·Yaping ChuJeffrey H Kordower
Apr 10, 2007·Trends in Neurosciences·David Sulzer
Jul 27, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·W Michael CaudleGary W Miller
Aug 22, 2008·Neurobiology of Aging·Nicholas M KanaanTimothy J Collier
Jun 19, 2009·Journal of Neuropathology and Experimental Neurology·William R MarkesberyFrederick A Schmitt
Oct 23, 2009·Annals of Neurology·C Warren Olanow, Jeffrey H Kordower
Oct 24, 2009·Neuroscience and Biobehavioral Reviews·Rachael D SeidlerDavid B Lipps
Nov 17, 2009·Nature Genetics·Javier Simón-SánchezThomas Gasser

❮ Previous
Next ❯

Citations

Jan 6, 2018·International Journal of Molecular Sciences·Joan Oliva
Feb 27, 2018·Cell and Tissue Research·Jennifer A SteinerPatrik Brundin
Jul 22, 2018·The FEBS Journal·Dalton James Surmeier
Jan 10, 2019·Annual Review of Pharmacology and Toxicology·Birgit Liss, Jörg Striessnig
Sep 27, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vibha PrasadAaron Voigt
Dec 18, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher Bishop
May 29, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Jared T HinkleTed M Dawson
Mar 15, 2018·Oncotarget·Beth GrimmigPaula C Bickford
Jun 25, 2020·Journal of Clinical Medicine·Bianca MarchettiNunzio Iraci
Jun 15, 2018·International Journal of Molecular Medicine·Yunlu JiangBo Bai
Dec 14, 2018·Aging·Thomas HentrichJulia M Schulze-Hentrich
Jan 17, 2019·Aging·Diana Luz Juarez-FloresGloria Garrabou
Mar 2, 2018·Current Medicinal Chemistry·Tommaso BonfiglioAnna Pittaluga
May 3, 2018·Journal of Neuroinflammation·Megan F DuffyCaryl E Sortwell
Oct 3, 2018·Aging and Disease·Yong-Fei ZhaoBao-Guo Xiao
Dec 14, 2018·Neurology·Stéphane PrangeStéphane Thobois
Oct 30, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Alastair J NoyceAndrew B Singleton
Aug 28, 2020·Frontiers in Aging Neuroscience·Ana Luisa Gil-MartinezMaria Trinidad Herrero
Oct 6, 2020·Oxidative Medicine and Cellular Longevity·Fangzhou Jiao, Zuojiong Gong
May 14, 2020·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Claudia Feitosa-SantanaDora Fix Ventura
Aug 16, 2018·Frontiers in Immunology·Marissa L DubbelaarErik W G M Boddeke
Aug 21, 2019·Translational Neurodegeneration·Shirley Yin-Yu PangShu-Leong Ho
May 18, 2020·Journal of Huntington's Disease·Emily Machiela, Amber L Southwell
Mar 10, 2020·Journal of Neurochemistry·Olga CortiPhilip M Beart
May 20, 2020·International Journal of Molecular Sciences·Sandra Barata-AntunesAntónio J Salgado
Sep 20, 2020·Biomolecules·Loredana LeggioNunzio Iraci
May 13, 2018·Genes·Mario Rango, Nereo Bresolin
Apr 4, 2019·Frontiers in Pharmacology·Hayate JavedShreesh Kumar Ojha
May 19, 2019·Neurotoxicity Research·Olga Corti
Sep 12, 2020·Cells·Enrico Zampese, D James Surmeier
Dec 19, 2018·Frontiers in Cellular Neuroscience·Ana Luisa Gil-MartínezMaría Trinidad Herrero
Jan 11, 2020·Frontiers in Neurology·Alexander KilzheimerJulia M Schulze-Hentrich
Oct 6, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zhen-Yu ShuMinming Zhang
Jan 12, 2021·Frontiers in Aging Neuroscience·Lei CuiJian-Hong Zhu
Jan 12, 2021·Frontiers in Cellular Neuroscience·Shuheng WenKoichi Uemura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Atypical Parkinsonism (MDS)

Atypical Parkinsonism presents with the same signs and symptoms of Parkinson's disease, but do not respond to typical Parkionson's disease treatment with levodopa. Atypical Parkinsonism is thought to be associated with abnormal protein buildup within brain cells. Here is the latest on Atypical Parkinsonism.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.