Aging and the immune response to organ transplantation

The Journal of Clinical Investigation
Monica M ColvinDaniel R Goldstein

Abstract

An increasing number of older people receive organ transplants for various end-stage conditions. Although organ transplantation is an effective therapy for older patients (i.e., older than 65 years of age), such as in end-stage renal disease, this therapy has not been optimized for older patients because of our lack of understanding of the effect of aging and the immune response to organ transplantation. Here, we provide an overview of the impact of aging on both the allograft and the recipient and its effect on the immune response to organ transplantation. We describe what has been determined to date, discuss existing gaps in our knowledge, and make suggestions on necessary future studies to optimize organ transplantation for older people.

References

Mar 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B L Kasiske
Mar 1, 1993·Transplantation·G I SnellJ R Maurer
Jan 9, 1998·Transplantation·S HariharanE P Cohen
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·D T Lucas, L I Szweda
Jun 6, 1998·Experimental Gerontology·N BoucherF Schächter
May 5, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·D F Del RizzoW J Kostuk
Sep 29, 1999·Transplantation Proceedings·M G Crespo-LeiroA Castro-Beiras
Feb 7, 2001·Transplantation·H U Meier-KriescheB Kaplan
Sep 16, 2000·Rheumatic Diseases Clinics of North America·R L Yung
Oct 25, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M LoebeR Hetzer
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·G G Garcia, R A Miller
Mar 7, 2001·International Urology and Nephrology·J S Cameron
Mar 10, 2001·The Journal of Thoracic and Cardiovascular Surgery·C BlancheA Trento
Mar 22, 2001·Kidney International·H U Meier-KriescheB Kaplan
Feb 6, 2002·The Journal of Experimental Medicine·Xiaohong ZhangJonathan Sprent
May 8, 2002·The Journal of Clinical Investigation·Rainer OrdemannJames L M Ferrara
May 25, 2002·Journal of the American Geriatrics Society·Stuart M Flechner
Sep 10, 2002·Transplant Immunology·Benjamin A Bradley
Jun 19, 2003·The Journal of Clinical Investigation·Andrew B AdamsChristian P Larsen
Jul 25, 2003·The Journal of Thoracic and Cardiovascular Surgery·Philippe DemersRobert C Robbins
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Laura HaynesSusan L Swain
Jan 27, 2004·The Journal of Pharmacology and Experimental Therapeutics·Jill S WarringtonLisa L von Moltke
Jan 30, 2004·Nature Immunology·Phyllis Jean Linton, Kenneth Dorshkind
May 19, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Bertram L KasiskeChangchun Wang
May 21, 2005·Drugs & Aging·Johan W de Fijter
Jun 4, 2005·Clinical and Experimental Immunology·R GreggP A Moss
Oct 26, 2005·Shock·Tomohisa OkayaAlex B Lentsch
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomohisa NishiokaShimon Sakaguchi
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sanjay SharmaJoseph Lustgarten
Dec 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shuji NoboriKazuhiko Yamada
Jan 30, 2007·The Journal of Thoracic and Cardiovascular Surgery·Marc De PerrotShaf Keshavjee
Apr 25, 2007·Hypertension·Mingyi WangEdward G Lakatta
Nov 4, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B M TesarD R Goldstein
Sep 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hirotake TsukamotoSusan L Swain
Nov 23, 2010·Nature Reviews. Immunology·Grace Y Chen, Gabriel Nuñez
Feb 8, 2011·Seminars in Immunopathology·Melissa R Keller, William J Burlingham
Mar 18, 2011·The New England Journal of Medicine·Stefan G Tullius, Edgar Milford
Jun 17, 2011·Science Translational Medicine·Gaoping ZhaoShaoping Deng
Aug 30, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei DuDaniel R Goldstein
Oct 4, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marshall I HertzJosef Stehlik

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Citations

Sep 8, 2017·British Journal of Clinical Pharmacology·Teun van Gelder
Jul 23, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Oliver K JawitzCarmelo Milano
Oct 3, 2019·Current Opinion in Nephrology and Hypertension·Lavanya Kodali, Alexandra Turner
Jun 5, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Judy ChenDaniel R Goldstein
Jul 13, 2020·Clinical Transplantation·Andrea LechiancoleUgolino Livi
Nov 6, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Chien-Chia ChenMeng-Kun Tsai
Jul 17, 2019·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Gregory SnellGlen Westall
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Zhihua LuMing Pei
Mar 31, 2021·International Journal of Clinical Oncology·Hideki Ikeda, Yosuke Togashi
Apr 30, 2021·BJOG : an International Journal of Obstetrics and Gynaecology·B P JonesUNKNOWN Royal College of Obstetricians and Gynaecologists
May 23, 2021·Transplantation Proceedings·Yu SatoMasafumi Nakamura
Jul 3, 2021·Current Transplantation Reports·Wisit CheungpasitpornDavid A Axelrod
Nov 24, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Ky-Leigh AngUsman Khalid

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Methods Mentioned

BETA
gene knockout

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