PMID: 15374281Sep 1, 1994Paper

Aging and the liver: functional aspects

Archives of Gerontology and Geriatrics
Kenichi Kitani

Abstract

The drastic decline in the function of the hepatic microsomal cytochrome monooxygenase system, initially reported in male rat livers, was shown to be due to a feminization of male rat livers with aging. In female rat livers as well as in mouse livers, this system was found to stay unchanged with age. Phase II reactions which showed some decline with aging in male rat livers again stayed fairly stable with age in female rat and mouse livers. Glutathione S-transferase (GST) enzyme activities, which are very stable with age in female rat and mouse livers, demonstrated highly age-dependent changes when dietary conditions were manipulated, suggesting a potential age difference in the homeostatic regulation of this enzyme system. Using the fluorescence recovery after photobleaching (FRAP) technique, unique studies revealed an age-dependent decline in the lateral mobility of proteins in hepatocyte surface membranes. The protease inhibitor model of aging, initially proposed by Ivy for brain cells, has been validated in hepatocytes, demonstrating an accumulation of lipofuscin-like granules in young animals treated with i.p. infusion of leupeptin for only 2 weeks. Antioxidant enzyme activities such as superoxide dismutase (SOD) and catal...Continue Reading

References

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Citations

Aug 12, 1998·BioFactors·N SanzM Cascales
Sep 2, 1998·Mechanisms of Ageing and Development·C A La PortaR Comolli
May 1, 1997·Experimental Gerontology·A PlewkaD Plewka
Oct 6, 1997·Journal of Hepatology·N SanzM Cascales
Jan 12, 1999·Toxicology and Applied Pharmacology·N SanzM Cascales
May 29, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Bradley H CollinsDon C Rockey
Jun 1, 2019·PeerJ·Jianning ChenYanzhi Jiang

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