Aging-associated changes in cerebral vasculature and blood flow as determined by quantitative optical coherence tomography angiography

Neurobiology of Aging
Yuandong LiRuikang K Wang

Abstract

Normal aging is associated with significant alterations in brain's vascular structure and function, which can lead to compromised cerebral circulation and increased risk of neurodegeneration. The in vivo examination of cerebral blood flow (CBF), including capillary beds, in aging brains with sufficient spatial detail remains challenging with current imaging modalities. In the present study, we use 3-dimensional (3-D) quantitative optical coherence tomography angiography (OCTA) to examine characteristic differences of the cerebral vasculatures and hemodynamics at the somatosensory cortex between old (16 months old) and young mice (2 months old) in vivo. The quantitative metrics include cortical vascular morphology, CBF, and capillary flow velocity. We show that compared with young mice, the pial arterial tortuosity increases by 14%, the capillary vessel density decreases by 15%, and the CBF reduces by 33% in the old mice. Most importantly, changes in capillary velocity and heterogeneity with aging are quantified for the first time with sufficiently high statistical power between young and old populations, with a 21% (p < 0.05) increase in capillary mean velocity and 19% (p ≤ 0.05) increase in velocity heterogeneity in the latter...Continue Reading

Citations

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Oct 17, 2019·Annual Review of Physiology·T Michael De Silva, Frank M Faraci
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Mar 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Melissa LieuWalter J Koch
Jul 9, 2020·Biomedical Optics Express·Yuandong LiRuikang K Wang
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