Aging-associated changes in hippocampal glycogen metabolism in mice. Evidence for and against astrocyte-to-neuron lactate shuttle

Glia
Dominika Drulis-FajdaszDariusz Rakus

Abstract

Lactate derived from astrocytic glycogen has been shown to support memory formation in hippocampi of young animals, inhibiting it in old animals. Here we show, using quantitative mass spectrometry-based proteomics, immunofluorescence, and qPCR that aging is associated with an increase of glycogen metabolism enzymes concentration and shift in their localization from astrocytes to neurons. These changes are accompanied with reorganization of hippocampal energy metabolism which is manifested by elevated capacity of aging neurons to oxidize glucose in glycolysis and mitochondria, and decreased ability for fatty acids utilization. Our observations suggest that astrocyte-to-neuron lactate shuttle may operate in young hippocampi, however, during aging neurons become independent on astrocytic lactate and the metabolic crosstalk between the brain's cells is disrupted.

References

Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·L Pellerin, P J Magistretti
Sep 14, 2004·The Journal of Biological Chemistry·Sébastien SerresMichel Merle
Jun 6, 2006·Neuroscience·M E GibbsL Hertz
Oct 30, 2007·Nature Neuroscience·Pierre J Magistretti, Igor Allaman
Nov 22, 2007·Human Molecular Genetics·Maria Carmen Solaz-FusterSantiago Rodriguez de Córdoba
Apr 17, 2008·American Journal of Physiology. Endocrinology and Metabolism·Biao FengSubrata Chakrabarti
Jul 9, 2008·Journal of Molecular Neuroscience : MN·Enrica BodaFilippo Tempia
Jan 13, 2009·Neuroscience·W M FreemanW E Sonntag
May 5, 2009·Experimental Cell Research·Kristin MöpertAnsgar Santel
Oct 8, 2009·Human Molecular Genetics·Hsiuchen Chen, David C Chan
Oct 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Huan MaSumiko Mochida
Nov 5, 2010·Molecular & Cellular Proteomics : MCP·Dirk M Walther, Matthias Mann
Dec 15, 2010·Biochemical and Biophysical Research Communications·Jerzy MozrzymasDarek Rakus
Mar 8, 2011·Cell·Akinobu SuzukiCristina M Alberini
Jun 8, 2011·Frontiers in Aging Neuroscience·Heather D Vanguilder, Willard M Freeman
Oct 27, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Luc Pellerin, Pierre J Magistretti
Jan 6, 2012·Nature Reviews. Neuroscience·Zu-Hang Sheng, Qian Cai
Mar 10, 2012·Frontiers in Neuroenergetics·Linea F ObelArne Schousboe
May 5, 2012·Molecular and Cellular Neurosciences·Grzegorz WieraJerzy W Mozrzymas
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Dec 4, 2012·Nucleic Acids Research·Juan Antonio VizcaínoHenning Hermjakob
Jul 12, 2014·Korean Journal of Pathology·Hye Jeong KimJong Tae Park
Jul 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jiangyan YangPierre J Magistretti
Sep 17, 2014·Molecular & Cellular Proteomics : MCP·Jacek R WiśniewskiMatthias Mann
Apr 4, 2015·Analytical Chemistry·Jacek R Wiśniewski, Fabienne Z Gaugaz
Apr 18, 2015·Journal of Neuroscience Research·Cecilie MorlandLinda Hildegard Bergersen
Apr 24, 2015·Nature Communications·Iben LundgaardMaiken Nedergaard
Apr 29, 2015·Frontiers in Cellular Neuroscience·Przemysław KaczorJerzy W Mozrzymas
Jun 24, 2015·Oncotarget·Dominika Drulis-FajdaszDariusz Rakus
Aug 22, 2015·The Journal of Physiology·Fei YinEnrique Cadenas
Jan 1, 2013·Journal of Neurodegenerative Diseases·Jordan T NewingtonRobert C Cumming
Nov 3, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Elena DolgodilinaVictoria Makrides
Jun 16, 2016·Journal of Proteome Research·Dariusz RakusJacek R Wiśniewski

❮ Previous
Next ❯

Citations

Sep 25, 2018·Expert Opinion on Therapeutic Targets·Przemysław DudaAgnieszka Gizak
Jan 25, 2019·Journal of Neuroscience Research·Hajime HiraseYuki Oe
Feb 8, 2019·Frontiers in Neuroscience·Carlos-Alberto GonçalvesMarina C Leite
Nov 22, 2019·Frontiers in Neuroscience·Laura R RichAngus M Brown
Mar 18, 2021·Aging Cell·Ruin MoaddelLuigi Ferrucci
May 28, 2021·Neurobiology of Aging·Margarita GerouScott P Allen
Jul 3, 2021·International Journal of Molecular Sciences·Kinga Gostomska-PampuchDariusz Rakus
Jun 13, 2021·Progress in Neurobiology·Shuai ZhangXiaofeng Jia
Jul 2, 2021·Frontiers in Aging Neuroscience·Ivan GeXinxing Wang
Aug 22, 2021·Antioxidants & Redox Signaling·Nicole G Rummel, D Allan Butterfield

❮ Previous
Next ❯

Datasets Mentioned

BETA
PXD006815

Methods Mentioned

BETA
PCR

Software Mentioned

SigmaPlot
Roche LightCycler 480 Analysis
MaxQuant
Cell
Fiji

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.