Aging attenuates adenosine triphosphate-induced, but not muscarinic and nicotinic, cutaneous vasodilation in men

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Naoto FujiiGlen P Kenny

Abstract

We evaluated the hypothesis that aging attenuates muscarinic, nicotinic, and ATP-related cutaneous vasodilation. In 11 young (24 ± 4 years) and 11 older males (61 ± 8 years), CVC was assessed at 3 forearm skin sites that were infused with either: (i) methacholine (muscarinic receptor agonist, 5 doses: 0.0125, 0.25, 5, 100, 2000 mmol/L), (ii) nicotine (nicotinic receptor agonist, 5 doses: 1.2, 3.6, 11, 33, 100 mmol/L), or (iii) ATP (purinergic receptor agonist, 5 doses: 0.03, 0.3, 3, 30, 300 mmol/L). Each agonist was administered for 25 minutes per dose. We showed that CVC at all doses of methacholine did not differ between groups. Similarly, no between-group differences in CVC were observed during nicotine administration at all doses administered. By contrast, while no differences in CVC were measured during the administration of ATP at low (0.03 and 0.3 mmol/L) or high (300 mmol/L) concentrations, CVC was reduced in the older relative to the young males at moderate concentrations of ATP (3 mmol/L: 23 ± 6 vs 40 ± 13%max, 30 mmol/L: 62 ± 11 vs 83 ± 8%max, both P ≤ .05). We show that aging attenuates ATP-induced, but not muscarinic or nicotinic, cutaneous vasodilation in men.

References

Jan 1, 1992·The Japanese Journal of Physiology·H Izumi, K Karita
Jul 1, 1995·Journal of Applied Physiology·H L MartinW L Kenney
Apr 16, 2002·The British Journal of Dermatology·E HagforsenG Michaëlsson
Oct 17, 2002·Journal of Applied Physiology·Christopher T MinsonBrad W Wilkins
Dec 31, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Lacy A HolowatzChristopher T Minson
Jun 20, 2003·European Journal of Clinical Investigation·R G IJzermanC D A Stehouwer
Jan 22, 2005·The Journal of Physiology·Lacy A HolowatzW Larry Kenney
Oct 1, 2005·Autonomic Neuroscience : Basic & Clinical·Tanja SchlerethFrank Birklein
Jan 20, 2007·Journal of Applied Physiology·Kenichi KimuraCraig G Crandall
Nov 18, 2008·Metabolism: Clinical and Experimental·Luiz Guilherme Kraemer-AguiarEliete Bouskela
Mar 20, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jonathan E WingoCraig G Crandall
Apr 1, 2010·European Journal of Applied Physiology·Gary J HodgesNigel T Cable
May 29, 2010·Journal of Applied Physiology·Christopher T Minson
Sep 3, 2010·The Journal of Physiology·Brett S KirbyFrank A Dinenno
Jan 20, 2011·Clinical Science·Douglas R SealsAnthony J Donato
Aug 27, 2011·Journal of Applied Physiology·Megan M WennerNina S Stachenfeld
Apr 14, 2012·Circulation Research·Brian J North, David A Sinclair
Jul 11, 2012·The Journal of Physiology·Anne R CreceliusFrank A Dinenno
Nov 17, 2012·Journal of Applied Physiology·Daniel GagnonGlen P Kenny
Jan 5, 2013·European Journal of Applied Physiology·James PearsonJosé González-Alonso
Jan 15, 2013·Experimental Physiology·Brett S KirbyFrank A Dinenno
Aug 9, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Caroline J SmithW Larry Kenney
Jun 3, 2014·Journal of Physiological Anthropology·Yoshimitsu InoueNarihiko Kondo
Oct 28, 2014·Physiological Reports·Jill M StapletonGlen P Kenny
Aug 21, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Naoto FujiiGlen P Kenny
Dec 4, 2015·Microvascular Research·Jordan C PatikR Matthew Brothers
Jan 12, 2016·Acta Physiologica·C J Garland, K A Dora
Jul 22, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Naoto FujiiGlen P Kenny
Feb 9, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Naoto FujiiGlen P Kenny
Feb 17, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew A TuckerMatthew S Ganio
Mar 14, 2017·Microvascular Research·Gary J HodgesMarkos Klonizakis
Mar 16, 2017·Experimental Physiology·James A LangKevin A Smaller
Apr 26, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Megan M WennerDavid G Edwards

❮ Previous
Next ❯

Citations

May 31, 2019·Experimental Physiology·James A Lang
Sep 24, 2020·International Journal of Molecular Sciences·Derek StrassheimEvgenia Gerasimovskaya
Dec 8, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Naoto FujiiGlen P Kenny

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.