Aging augments mitochondrial susceptibility to heat stress.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Jodie L HaakKevin C Kregel

Abstract

The pathophysiology of aging is accompanied by a decline in tolerance to environmental stress. While mitochondria are primary suspects in the etiology of aging, little is known about their ability to tolerate perturbations to homeostasis in older organisms. To investigate the role of mitochondria in the increased susceptibility to heat stress that accompanies aging, young and old Fischer 344 rats underwent a heat stress protocol known to elicit exaggerated cellular damage with aging. At either 2 or 24 h after heat stress, livers were removed from animals, and hepatic mitochondria were isolated. Electron microscopy revealed extensive morphological damage to mitochondria from young and, to a greater extent, old rats after heat stress. There was also a significant loss of cytochrome c from old, but not young, mitochondria and a persistent increase in 4-hydroxynonenal-modified proteins in old vs. young mitochondria exposed to heat stress. Electron paramagnetic resonance measurements of superoxide indicate greater superoxide production from mitochondria of old compared with young animals and suggest that mitochondrial integrity was altered during heat stress. The mitochondrial stress response, which functions to correct stress-induc...Continue Reading

References

Oct 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J A DicksonK McLeod
Aug 1, 1970·The American Journal of Medicine·M KewG Kent
Jan 1, 1971·Transactions of the Royal Society of Tropical Medicine and Hygiene·M KewH Seftel
Jul 11, 1996·The New England Journal of Medicine·J C SemenzaJ L Wilhelm
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·B S PollaA Cossarizza
Aug 15, 1996·European Journal of Biochemistry·R D MartinusN J Hoogenraad
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·T M HagenB N Ames
Jun 1, 1997·The American Journal of Physiology·E E Craig, D A Hood
Jun 10, 1998·Biochemical and Biophysical Research Communications·L BornmanB S Polla
Jan 12, 1999·Toxicology and Applied Pharmacology·N SanzM Cascales
Jan 6, 2000·Archives of Biochemistry and Biophysics·L K Kwong, R S Sohal
Jul 27, 2000·Annals of the New York Academy of Sciences·D A CottrellD M Turnbull
Aug 5, 2000·Journal of Applied Physiology·D M HallK C Kregel
Sep 1, 2000·Frontiers in Bioscience : a Journal and Virtual Library·E Conway de Macario, A J Macario
Oct 24, 2000·International Journal of Clinical & Laboratory Research·A J Macario, E Conway de Macario
Feb 28, 2001·Experimental Gerontology·I M ReaA G Pockley
May 5, 2001·The American Journal of Pathology·I A SammutM H Yacoub
Jan 5, 2002·Journal of Bioenergetics and Biomembranes·H R McLennan, M Degli Esposti
Jan 15, 2002·MMWR. Morbidity and Mortality Weekly Report·UNKNOWN Centers for Disease Control and Prevention (CDC)
May 9, 2002·Biochimica Et Biophysica Acta·Barbara VenturaGiorgio Lenaz
Aug 29, 2002·The EMBO Journal·Quan ZhaoNicholas J Hoogenraad
Aug 30, 2002·The International Journal of Biochemistry & Cell Biology·David G Nicholls
Dec 17, 2002·Cell Stress & Chaperones·Renu WadhwaSunil C Kaul
Jan 14, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·K HeiseD Abele
Jan 14, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Atsuko TaruiRyo-Hei Yamada
Apr 24, 2003·Experimental Biology and Medicine·Maria Luisa GenovaGiorgio Lenaz
Aug 12, 2003·European Journal of Pharmacology·Shankar B SachidhanandamShabbir M Moochhala
Sep 23, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hannah J ZhangKevin C Kregel
Oct 17, 2003·The Journal of Physiology·Julio F Turrens
Nov 25, 2003·The New England Journal of Medicine·Philippe VanhemsJacques Fabry
May 6, 2004·Annals of the New York Academy of Sciences·Maria Luisa GenovaGiorgio Lenaz
Jul 13, 2004·Annals of the New York Academy of Sciences·Ricardo GredillaGustavo Barja
Jul 24, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ana Navarro, Alberto Boveris
Aug 4, 2004·Experimental Gerontology·Sergey Kamzalov, Rajindar S Sohal
Aug 5, 2004·American Journal of Physiology. Renal Physiology·David W GoodGary E Shull
Nov 17, 2004·Cell Stress & Chaperones·Lingjia QianSuqi Cheng
Jan 10, 2006·Annals of the New York Academy of Sciences·Vladimir P Skulachev, Valter D Longo
May 2, 2006·Ageing Research Reviews·Amie J DirksChristiaan Leeuwenburgh
May 9, 2006·Antioxidants & Redox Signaling·Giorgio LenazGiancarlo Solaini

❮ Previous
Next ❯

Citations

Dec 7, 2011·Cell Stress & Chaperones·Kishiko OgawaStuart K Calderwood
Sep 3, 2013·Archives of Gerontology and Geriatrics·Steven A BloomerKyle E Brown
Nov 21, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Basilia ZingarelliPaul W Hake
Mar 21, 2015·Scientific Reports·Chelsea McCallisterNikolas Nikolaidis
Nov 15, 2017·Cell Stress & Chaperones·Ryan Dennis Martinus, Julie Goldsbury
Dec 15, 2017·Lipids in Health and Disease·Steven A BloomerGregory C Henderson
Mar 6, 2016·The Journal of Experimental Biology·Aneta Książek, Marek Konarzewski
Jul 23, 2009·Molecular Carcinogenesis·Yan LiRobert C G Martin
Jan 22, 2015·The World Journal of Men's Health·Kaveri PurandharSriram Seshadri
May 7, 2010·The Journal of Animal Ecology·John R Speakman, Elzbieta Król
May 19, 2011·The EMBO Journal·Nikos Kourtis, Nektarios Tavernarakis
Nov 7, 2019·Histochemistry and Cell Biology·Steven A BloomerKevin C Kregel
Jan 21, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Steven A Bloomer, Eric D Moyer
May 29, 2018·Journal of Thermal Biology·Shanthi GanesanJoshua T Selsby

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.