Aging, Cellular Senescence, and Progressive Multiple Sclerosis

Frontiers in Cellular Neuroscience
Dimitrios PapadopoulosRichard S Nicholas

Abstract

Aging is one of the most important risk factors for the development of several neurodegenerative diseases including progressive multiple sclerosis (MS). Cellular senescence (CS) is a key biological process underlying aging. Several stressors associated with aging and MS pathology, such as oxidative stress, mitochondrial dysfunction, cytokines and replicative exhaustion are known triggers of cellular senescence. Senescent cells exhibit stereotypical metabolic and functional changes, which include cell-cycle arrest and acquiring a pro-inflammatory phenotype secreting cytokines, growth factors, metalloproteinases and reactive oxygen species. They accumulate with aging and can convert neighboring cells to senescence in a paracrine manner. In MS, accelerated cellular senescence may drive disease progression by promoting chronic non-remitting inflammation, loss or altered immune, glial and neuronal function, failure of remyelination, impaired blood-brain barrier integrity and ultimately neurodegeneration. Here we discuss the evidence linking cellular senescence to the pathogenesis of MS and the putative role of senolytic and senomorphic agents as neuroprotective therapies in tackling disease progression.

References

Jan 29, 1998·The New England Journal of Medicine·B D TrappL Bö
Dec 10, 1999·Experimental Cell Research·C B JohanssonJ Frisén
Sep 23, 2003·Journal of Neurocytology·Richard ReynoldsJoel Levine
Jan 20, 2004·Glia·Wolfgang J StreitD Larry Sparks
Feb 3, 2004·Nature Cell Biology·Olga A SedelnikovaJ Carl Barrett
Jan 25, 2005·Mechanisms of Ageing and Development·Thomas B L KirkwoodRudi G J Westendorp
Aug 30, 2005·Annals of the New York Academy of Sciences·Marielle ThewissenPiet Stinissen
Dec 13, 2005·Experimental Neurology·Dimitrios PapadopoulosRichard Reynolds
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark R KotterRobin J M Franklin
Jan 20, 2006·The European Journal of Neuroscience·Alexandre I DanilovLou Brundin
Jan 27, 2006·Molecular Biology of the Cell·Olga MoiseevaGerardo Ferbeyre
May 3, 2006·Journal of Neuropathology and Experimental Neurology·Jessica R Conde, Wolfgang J Streit
Jul 28, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bénédicte MennArturo Alvarez-Buylla
Jan 26, 2007·Journal of Neurochemistry·M PertusaR Cristòfol
Mar 24, 2007·Rejuvenation Research·Barry E FlanaryWolfgang J Streit
Mar 29, 2007·Brain Pathology·Hans LassmannClaudia F Lucchinetti
Apr 20, 2007·Neuropathology and Applied Neurobiology·R PataniR Reynolds
Sep 18, 2007·Neurobiology of Aging·Andrew J Farrall, Joanna M Wardlaw
Jun 19, 2008·Annual Review of Neuroscience·Bruce D Trapp, Klaus-Armin Nave
Jun 24, 2008·Annals of Neurology·Leonora K FisnikuDavid H Miller
Aug 2, 2008·Brain : a Journal of Neurology·Ansi ChangBruce D Trapp
Oct 31, 2008·Lancet·Alastair Compston, Alasdair Coles
Nov 19, 2008·Epigenetics & Chromatin·Asako J NakamuraWilliam M Bonner
Jan 10, 2009·Nature Reviews. Cancer·Thomas Kuilman, Daniel S Peeper
Jan 23, 2009·Nature Neuroscience·Siming ShenPatrizia Casaccia-Bonnefil
Mar 19, 2009·Brain : a Journal of Neurology·Don J MahadDouglass M Turnbull
Jun 27, 2009·Annual Review of Neuroscience·Arnold Kriegstein, Arturo Alvarez-Buylla
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Hoonkyo SuhFred H Gage
Nov 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sacri R FerrónIsabel Fariñas
Jan 19, 2010·Annual Review of Pathology·Jean-Philippe CoppéJudith Campisi
Apr 8, 2010·International Journal of Oncology·Maki IkedaTakashi Sawai
Apr 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yuki KujuroToru Kondo
Jul 3, 2010·Neurobiology of Aging·Makoto HoriuchiCharles Decarli
Jul 14, 2010·Experimental Cell Research·Alessandro BittoClaudio Torres
Sep 22, 2010·Brain : a Journal of Neurology·Stephan BramowHenning Laursen
Dec 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Richa B TripathiWilliam D Richardson

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Citations

Dec 5, 2020·Pharmacology & Therapeutics·Ibrahim Y AbdelgawadBeshay N Zordoky
May 1, 2021·International Journal of Molecular Sciences·Eleanor K Greenwood, David R Brown
May 19, 2021·Tissue Engineering and Regenerative Medicine·Seokhyeong GoByung-Soo Kim
Jun 15, 2021·Expert Opinion on Investigational Drugs·Rujapope SutiwisesakArthur E Warrington
May 15, 2021·Current Opinion in Neurology·Hans-Peter HartungGiancarlo Comi
Jun 29, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ana Rita RibeiroAdelaide Fernandes
Aug 10, 2021·Multiple Sclerosis and Related Disorders·Annalise E Miner, Jennifer S Graves

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transgenic

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