Aging deteriorates quality of sperm produced by male mice with partial Yq deletion

Systems Biology in Reproductive Medicine
Katarzyna KotarskaJózefa Styrna

Abstract

The aim of the study was to assess the cumulative effects of aging and Y-chromosome long arm deletion on sperm quality parameters. Motility, mitochondrial activity, and head morphology were evaluated for sperm of 3- and 12-month-old males from B10.BR-Ydel and B10.BR congenic mouse strains. The study revealed that quality and fertilizing potential of sperm produced by younger and older B10.BR males persist on similar levels, but worsen significantly with age of B10.BR-Ydel males. The findings imply that partial Yq deletions might be more harmful for spermiogenesis in advancing age and may be applicable to other species including humans. AZF: azoospermia factor; MSYq: male-specific region of the Y-chromosome long arm.

References

May 1, 1991·Journal of Reproduction and Fertility·J StyrnaK Moriwaki
May 28, 2011·Folia Biologica·Katarzyna Kotarska, Małgorzata Lenartowicz
Feb 6, 2017·Fertility and Sterility·Michael L Eisenberg, David Meldrum
Feb 6, 2017·Fertility and Sterility·Amin S HeratiDolores J Lamb
Jun 17, 2010·Reproductive Medicine and Biology·Eitetsu KohMikio Namiki

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Citations

May 28, 2021·Current Protocols·Glenn LongeneckerAshok B Kulkarni

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