Aging does not affect the ability of human monocyte-derived dendritic cells to phagocytose Candida albicans

Aging Clinical and Experimental Research
Magda Paula Pereira do NascimentoVanessa Soares Lara

Abstract

Dendritic cells (DCs) are the most potent antigen-presenting cells, playing a key role in induction of both innate and adaptive immunity. Immunosenescence refers to age-associated changes in the immune system, which may be associated with susceptibility to infections and their clinical complications. The precise effects of aging on DCs in immunity to infections are not well understood. Among the common pathogenic microorganisms, the fungus Candida albicans is an important pathogen for the development of invasive infections, especially in immunocompromised individuals, as well as during aging. To make a comparative in vitro evaluation of the immunomodulatory function of DCs challenged with C. albicans, by phagocytosis of the fungal cells, and determine the involvement of TLR2 and TLR4 receptors. For this purpose, DCs were generated with the use of peripheral blood monocytes from healthy young and aged subjects. The phagocytosis of C. albicans is developed by DCs in TLR2- and TLR4-dependent way. This mechanism is not affected by aging. Given the important role of the DCs in responses against the fungus, it is evident that if changes in phagocytosis occurred with aging, impairment in the elderly could develop. However, the evidenc...Continue Reading

References

Jan 27, 2000·Journal of Leukocyte Biology·C WenischW Hörl
Jul 20, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C A Kauffman
Jul 23, 2004·Aging Cell·Julie PlowdenSuryaprakash Sambhara
Jan 21, 2006·Nature Immunology·Marco ColonnaAkiko Iwasaki
Nov 15, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Silvia Della BellaMaria L Villa
Dec 22, 2006·Experimental Gerontology·Anshu AgrawalSudhir Gupta
Jul 26, 2008·Medical Mycology·Louis Y A ChaiBart-Jan Kullberg
Mar 31, 2009·Immunity & Ageing : I & a·Thaís Helena GasparotoVanessa Soares Lara
Jan 27, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander PandaAlbert C Shaw
Jun 25, 2010·Australian Dental Journal·C S FarahM J McCullough
Jul 14, 2010·Ageing Research Reviews·Anshu Agrawal, Sudhir Gupta
Jul 29, 2010·Journal of Oral Rehabilitation·T H GasparotoV S Lara
Nov 16, 2010·Ageing Research Reviews·Albert C ShawRuth R Montgomery
May 17, 2011·Cellular Immunology·Antonio CiaramellaPaola Bossù
Nov 29, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T H GasparotoV S Lara
Dec 14, 2011·Expert Review of Clinical Immunology·Anshu AgrawalHarsh Agrawal
Aug 14, 2012·Indian Journal of Medical Microbiology·S Giri, A J Kindo
Apr 16, 2013·Immunobiology·Jialu YouParveen Yaqoob
Jun 14, 2013·Immunity & Ageing : I & a·Karen Henriette PinkeVanessa Soares Lara
Dec 29, 2013·Experimental Gerontology·Sudhir Gupta
Apr 29, 2014·Current Opinion in Immunology·Fabiola OlivieriRuth R Montgomery

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Citations

Jul 2, 2016·Clinical and Experimental Immunology·T FulopA Larbi
Sep 7, 2016·European Journal of Immunology·Marcello PintiAndrea Cossarizza
Feb 10, 2018·Oral Diseases·A C KeşoğluH Bilhan
Sep 15, 2017·Critical Reviews in Food Science and Nutrition·Elisavet Stavropoulou, Eugenia Bezirtzoglou
Jan 29, 2020·Antioxidants & Redox Signaling·Helen R GriffithsYvonne Perrie

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