PMID: 11933895Apr 6, 2002Paper

Aging effects on memory encoding in the frontal lobes

Psychology and Aging
Glenn T StebbinsJohn D E Gabrieli

Abstract

Functional magnetic resonance imaging (fMRI) was used to compare frontal-lobe activation in younger and older adults during encoding of words into memory. Participants made semantic or nonsemantic judgments about words. Younger adults exhibited greater activation for semantic relative to nonsemantic judgments in several regions, with the largest activation in the left inferior frontal gyrus. Older adults exhibited greater activation for semantic judgments in the same regions. but the extent of activation was reduced in left prefrontal regions. In older adults, there was a significant association between behavioral tests of declarative and working memory and extent of frontal activation. These results suggest that age-associated decreases in memory ability may be due to decreased frontal-lobe contributions to the initial encoding of experience.

Citations

Aug 25, 2007·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Michaela T DewarSergio Della Sala
Dec 10, 2002·Neuroscience and Biobehavioral Reviews·Florin DolcosRoberto Cabeza
Aug 21, 2003·Neurobiology of Aging·Sander M DaselaarCees Jonker
Aug 30, 2002·Trends in Cognitive Sciences·Patricia Reuter-Lorenz
Oct 11, 2007·Cerebral Cortex·Simon W DavisRoberto Cabeza
Nov 19, 2008·Social Cognitive and Affective Neuroscience·Tatia M C LeeChetwyn C H Chan
Oct 23, 2009·Restorative Neurology and Neuroscience·Joshua O Goh, Denise C Park
Apr 14, 2010·Social Cognitive and Affective Neuroscience·Amy WinecoffScott A Huettel
Nov 25, 2011·Cerebral Cortex·Ilana T Z DewRoberto Cabeza
May 1, 2011·Therapeutic Advances in Chronic Disease·Arthur A SimenLisa C Barry
Dec 17, 2011·Journal of Aging Research·Evan T SchulzeDeborah M Little
Jan 17, 2019·Cognitive Neuroscience·Cassandra MorrisonVanessa Taler
Nov 3, 2016·Frontiers in Aging Neuroscience·Mohit RanaNatalie C Ebner

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