Abstract
Programming of offspring life-course health by maternal nutrition and stress are well studied. At postnatal day 850, we evaluated male and female steroid levels and metabolism in aged offspring of primigravid sister rats bred at 70, 90, 150, or 300 days' life. At 850 days life, male offspring corticosterone was similar regardless of maternal age. Female corticosterone was highest in offspring of 70- and 300-day mothers. Serum dehydroepiandrosterone:corticosterone was lowest in both sexes of offspring of 70- and 300-day mothers. Male and female fat depots were smaller in offspring of 150- than 70- and 90-day mothers. Insulin, glucose, and homeostatic model assessment were similar in all male offspring but higher in female offspring of 70-day mothers than other ages. We conclude, maternal age affects offspring aging in an offspring sex-dependent manner and merits consideration in designing and interpreting programming studies.
References
Sep 1, 1984·The Journal of Clinical Endocrinology and Metabolism·N OrentreichJ H Vogelman
May 12, 2005·Life Sciences·Jorge Reis Almeida, Carlos Alberto Mandarim-de-Lacerda
Jul 15, 2005·Pharmacogenomics
Dec 25, 2007·Experimental Biology and Medicine·P C LisboaE G Moura
Apr 25, 2009·Behavioural Brain Research·Yvonne MartínezRoberto A Prado-Alcalá
Aug 13, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Bruce A CarnesIngo Schlupp
Oct 31, 2014·Age·Guadalupe L Rodríguez-GonzálezElena Zambrano
May 9, 2015·Age·E ZambranoP W Nathanielsz
Dec 15, 2015·The Journal of Physiology·Claudia C VegaElena Zambrano
Mar 5, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Beth J AllisonDino A Giussani
Oct 4, 2016·Paediatric Respiratory Reviews·Erin V McGillickJanna L Morrison
Aug 11, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mais M AljunaidySandra T Davidge
Oct 19, 2017·PloS One·Samantha C LeanAlexander E P Heazell
Jan 13, 2018·Gerontology·Joshua D PrestonKevin J Pearson
Jul 6, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jane L Tarry-AdkinsSusan E Ozanne
Jul 31, 2018·Ageing Research Reviews·Alexander VaisermanOleh Lushchak
Aug 24, 2018·IBRO Reports·Roelf J Cruz-RizzoloEdson Aparecido Liberti
Oct 6, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Amin ShahSandra T Davidge
Feb 9, 2019·The Journal of Physiology·Yeukai T M MangwiroMary E Wlodek
Feb 26, 2019·Aging Cell·Catherine J ChengJames F Nelson
Jun 15, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Christy-Lynn M Cooke, Sandra T Davidge