Aging, exercise, and cardioprotection

Annals of the New York Academy of Sciences
Scott K PowersKaryn L Hamilton

Abstract

Myocardial ischemia-reperfusion (I-R) injury is a major contributor to the morbidity and mortality associated with coronary artery disease. The incidence of I-R events is greatest in older persons, and studies also indicate that the magnitude of myocardial I-R injury is greater in senescent individuals compared to younger adults. Regular exercise has been confirmed as a pragmatic countermeasure to protect against I-R-induced cardiac injury. Specifically, endurance exercise has been proven to provide cardioprotection against an I-R insult in both young and old animals. Proposed mechanisms to explain the cardioprotective effect of exercise include the induction of myocardial heat shock proteins (HSPs), improved cardiac antioxidant capacity, and/or elevation of other cardioprotective proteins. Of these potential mechanisms, evidence indicates that elevated myocardial levels of heat shock proteins or antioxidants can provide myocardial protection against I-R injury. At present, which of these protective mechanisms is essential for exercise-induced cardioprotection remains unclear. Understanding the molecular basis for exercise-induced cardioprotection is important in developing exercise paradigms to protect the heart during an I-R ...Continue Reading

References

Apr 30, 1999·Physiological Reviews·R Bolli, E Marbán
Jun 8, 1999·The Journal of Experimental Medicine·N YamashitaM Hori
Jul 23, 1999·Medicine and Science in Sports and Exercise·S K PowersC Leeuwenburgh
Sep 6, 2000·Clinical and Experimental Pharmacology & Physiology·S Pepe
Oct 20, 2001·Journal of Applied Physiology·H A DemirelH Naito
Jul 4, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Edward G Lakatta, Steven J Sollott
Feb 22, 2003·Physiological Genomics·Michael G EdwardsTomas A Prolla
Mar 22, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Joseph W StarnesYoonjung Park
Mar 26, 2003·Free Radical Biology & Medicine·Karyn L HamiltonScott K Powers
Jun 7, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Haydar A DemirelScott K Powers
Sep 6, 2003·Free Radical Biology & Medicine·Igor RebrinRajindar S Sohal

❮ Previous
Next ❯

Citations

Jan 4, 2008·Histochemistry and Cell Biology·Marina MariniArsenio Veicsteinas
Jan 8, 2010·The Journal of Physiological Sciences : JPS·John C QuindryScott Powers
Jan 30, 2009·Cardiovascular Research·Kerstin BoenglerGerd Heusch
Apr 29, 2009·Cardiovascular Research·Asger GranfeldtJakob Vinten-Johansen
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·R Dale BrownCarlin S Long
Jan 18, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Allison E DevanHirofumi Tanaka
Mar 20, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John M LawlerMin-Hwa Suk
Mar 12, 2009·Medicine and Science in Sports and Exercise·Sarit FreimannMickey Scheinowitz
Jul 21, 2009·Ageing Research Reviews·Pasquale AbeteFranco Rengo
Mar 1, 2008·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Biao SunJi Zheng Ma
Jan 15, 2008·Free Radical Biology & Medicine·Scott K PowersAndreas N Kavazis
Jul 15, 2009·International Journal of Cancer. Journal International Du Cancer·Gabriella MarfeMarco Tafani
Mar 3, 2007·The Journal of Pharmacy and Pharmacology·Aleksandar Jovanović
Mar 10, 2006·Experimental Gerontology·Zsolt MurlasitsStephen E Alway
Jun 30, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Cathy WyseKenneth Skeldon
Nov 19, 2014·Oxidative Medicine and Cellular Longevity·Weiwei WangYajun Zhao
Apr 14, 2012·International Journal of Cardiology·Viviane A BarbosaClaudio T De Souza
Jul 22, 2016·British Journal of Pharmacology·Louise E See HoeJason N Peart
Sep 9, 2017·Exercise and Sport Sciences Reviews·John C Quindry, Barry A Franklin
May 26, 2010·Korean journal of anesthesiology·Yon Hee Shim
Mar 12, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joshua T Selsby, Stephen L Dodd
Oct 16, 2009·Sports Medicine·Andreas N Kavazis
Sep 13, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Joel P FrenchScott K Powers
Feb 21, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Serena Viappiani, Richard Schulz
Jun 16, 2007·Journal of Applied Physiology·John C QuindryScott K Powers
Aug 25, 2007·Journal of Applied Physiology·Arshad JahangirAndre Terzic
Dec 18, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Andreas N KavazisScott K Powers
Apr 9, 2011·Journal of Applied Physiology·Anna VainshteinDavid A Hood
Jul 2, 2021·Journal of Applied Physiology·Elizabeth A SchroderGerald S Supinski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.