PMID: 16628066Apr 22, 2006Paper

Aging: impact upon local cerebral oxygenation and blood flow with acute isovolemic hemodilution

Journal of Neurosurgical Anesthesiology
Min LiThomas F Floyd

Abstract

Data from the neurosurgical critical care arena demonstrate a correlation between cerebral oxygenation, survival, and cognitive function. Transfusion may increase and hemodilution decrease cerebral oxygenation. Both acute and chronic anemia have been associated with cognitive dysfunction. Aggressive blood conservation protocols have been instituted across all age groups without conclusive evidence for their impact upon outcome. Aged subjects are at the greatest risk of cognitive sequelae after major surgery associated with significant blood loss. We hypothesize that cerebral physiologic changes associated with "normal" aging may compromise cerebral oxygenation in the presence of severe anemia.Fischer 344 rats, the NIH National Institute of Aging normal aging rat model, underwent a stepwise isovolemic hemodilution protocol. Age groups (Age Grp) studied were as follows: Age Grp-A (3 months), n=14; Age Grp-B (9 to 12 months), n=14; and Age Grp-C (24 months), n=14. Brain oxygen tension (PBrO2), laser Doppler flow, and mean arterial pressure were measured. Final hemoglobin averaged 6.1+/-0.9 g/dL. PBrO2 levels decreased from a baseline of 18.1+/-4.1 to 17.5+/-6.8 mm Hg (P=0.49), and laser Doppler flow increased by 18+/-20% (P<0.0001...Continue Reading

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Citations

Nov 6, 2010·Cerebral Cortex·Hanzhang LuDenise C Park
Sep 21, 2011·Paediatric Anaesthesia·Gianluca BertolizioAndre Obenaus
Apr 7, 2007·Journal of Neurosurgical Anesthesiology·Jeffrey J Pasternak, William L Lanier
Sep 26, 2007·Anesthesiology·Joseph P MathewUNKNOWN Neurologic Outcome Research Group (NORG) of the Duke Heart Center
Mar 30, 2021·Anesthesia and Analgesia·Brina SnyderThomas F Floyd

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