Aging increases the susceptibility to develop anhedonia in male rats

Progress in Neuro-psychopharmacology & Biological Psychiatry
José Jaime Herrera-PérezA Fernández-Guasti

Abstract

The objective of this study was to establish the effect of aging on the development of anhedonia, a core feature of depression. Young and old male Wistar rats (of around 3-5 and 12-15 months, respectively) were exposed to a chronic variable stress (CVS) schedule for 3 weeks. CVS produced anhedonia, indicated by a reduction in the intake of a sucrose solution (1%), in 8 out of 23 (35%) young rats and in 19 out of 26 (73%) old rats, implying that old animals are more susceptible to stress and develop anhedonia more readily than young animals. Young and old anhedonic rats showed a similar temporal course in the reduction of sucrose consumption, reaching the anhedonic state after 2 weeks of CVS exposure. Compared with young animals, old rats had lower basal serum testosterone and estradiol levels. The systemic levels of corticosterone did not vary between both age groups. No significant pathological condition was detected in old animals. It is suggested that the higher susceptibility to develop anhedonia in male rats could be associated to neuroendocrine changes consequent to aging.

References

Feb 1, 1985·Biological Psychiatry·J A YesavageP A Berger
Oct 27, 1997·JAMA : the Journal of the American Medical Association·B D LebowitzP Parmelee
Oct 23, 1997·Science·S W LambertsA J van der Lely
Sep 9, 1999·Psychiatric Services : a Journal of the American Psychiatric Association·C F Reynolds, D J Kupfer
Jan 5, 2000·The American Journal of Psychiatry·J D BremnerD S Charney
Dec 14, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Riina HäidkindJaanus Harro
Jan 14, 2003·The Journal of Clinical Psychiatry·Paul J PerryTimothy L Holman
Dec 25, 2003·Journal of Gerontological Nursing·Gail Wagnild
Feb 6, 2004·Archives of General Psychiatry·Molly M ShoresDaniel R Kivlahan
Apr 16, 2004·Drugs & Aging·Ryan M Carnahan, Paul J Perry
Nov 25, 2004·Endocrine Reviews·Roy G SmithYuxiang Sun
Jan 27, 2005·The Journal of Clinical Psychiatry·Molly M ShoresDaniel R Kivlahan
Mar 2, 2005·Nature Reviews. Neuroscience·Eero Castrén
May 21, 2005·Behavioural Brain Research·Stathis BekrisZeta Papadopoulou-Daifoti
Jun 7, 2005·Lancet·George S Alexopoulos
Feb 17, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Magdalena N JayatissaOve Wiborg
Apr 3, 2007·European Archives of Psychiatry and Clinical Neuroscience·Barbara VollmayrFritz A Henn

❮ Previous
Next ❯

Citations

Jan 26, 2016·Pharmacology, Biochemistry, and Behavior·Alonso Fernández-GuastiLucía Martínez-Mota
Jun 2, 2012·Behavioural Brain Research·Soledad Récamier-CarballoAlonso Fernández-Guasti
Mar 1, 2012·Hormones and Behavior·José Jaime Herrera-PérezAlonso Fernández-Guasti
May 3, 2011·The Journal of Surgical Research·Yu-Bin ZhangJian-Ting Chen
Feb 4, 2010·European Journal of Pharmacology·José Jaime Herrera-PérezAlonso Fernández-Guasti
Feb 5, 2014·Behavioral and Brain Functions : BBF·Rosa-Elena UlloaLucía Martínez-Mota
Feb 12, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sandra Olvera-HernándezAlonso Fernández-Guasti
Jun 16, 2011·Pharmacology, Biochemistry, and Behavior·Sandra Olvera-Hernández, Alonso Fernández-Guasti
May 29, 2014·Behavioural Brain Research·Nelly M Vega-RiveraErika Estrada-Camarena
Feb 20, 2010·Behavioural Pharmacology·Mónica Romano-Torres, Alonso Fernández-Guasti
Jul 26, 2019·The Journal of Comparative Neurology·Rory PritchardDavide Dulcis
Nov 18, 2016·Aging·Veronika BorbélyováPeter Celec
Jan 1, 2013·Neuroscience Journal·José Jaime Herrera-PérezLucía Martínez-Mota
Jul 31, 2018·Frontiers in Psychology·Beáta KorcsokMárta Gácsi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.