Aging induced cortical drive alterations during sleep in rats

Mechanisms of Ageing and Development
Jelena CiricJasna Saponjic

Abstract

We followed the impact of healthy aging on cortical drive during sleep in rats by using the corticomuscular coherence (CMC). We employed the chronic electrodes implantation for sleep recording in adult, male Wistar rats, and followed the aging impact during sleep from 3 to 5.5 months age. We have analyzed the sleep/wake states architecture, and the sleep/wake state related EEG microstructure and CMCs. We evidenced the topographically distinct impact of aging on sleep/wake states architecture within the sensorimotor (SMCx) vs. motor cortex (MCx) from 4.5 to 5.5 months age. Healthy aging consistently altered only the SMCx sleep/wake states architecture, and increased the delta and beta CMCs through both cortical drives during Wake, but only through the MCx drive during REM. According to the delta and beta CMCs values, aging impact through the SMCx drive was opposite, but it was convergent through the MCx drive during Wake vs. REM, and there was a dual and inverse mode for the motor control during REM.

References

Dec 22, 1999·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·T Mima, M Hallett
Jan 6, 2000·Progress in Neurobiology·P Brown
Feb 16, 2000·Neurobiology of Aging·W B Mendelson, B M Bergmann
Mar 2, 2002·Brain : a Journal of Neurology·Stephan SaleniusPeter Brown
Apr 18, 2002·Neuroscience Letters·Roumen Kirov, Slavianka Moyanova
Jul 16, 2002·Pharmacology, Biochemistry, and Behavior·I FeinbergK Anderson
Sep 28, 2002·The International Journal of Neuroscience·Slavianka G MoyanovaLidia V Kortenska
Dec 10, 2002·Neuroscience and Biobehavioral Reviews·Ralf Th Krampe
Feb 4, 2003·The Journal of Physiology·Mark R Baker, Stuart N Baker
Dec 10, 2003·Current Opinion in Neurobiology·Stephan Salenius, Riitta Hari
Apr 28, 2004·NeuroImage·C Nicholas RiddleStuart N Baker
Aug 16, 2005·Journal of Chemical Neuroanatomy·Ken W S Ashwell, George Paxinos
Feb 3, 2007·Brain : a Journal of Neurology·Jennifer L WhitwellClifford R Jack
Apr 7, 2007·Brain : a Journal of Neurology·B F BoeveH Braak
Nov 6, 2008·Nature Reviews. Neuroscience·James M KruegerJaak Panksepp
Oct 24, 2009·Neuroscience and Biobehavioral Reviews·Rachael D SeidlerDavid B Lipps
Jun 20, 2014·Behavioural Brain Research·Jelena PetrovicJasna Saponjic

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Citations

Nov 5, 2016·Physiology & Behavior·Katarina LazicJasna Saponjic
May 31, 2020·Journal of Sleep Research·Jelena PetrovicJasna Saponjic
Mar 16, 2019·Frontiers in Neuroscience·Jelena CiricJasna Saponjic

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