PMID: 8597425Dec 29, 1995Paper

Aging is associated in the 344/N Fischer rat with decreased stress responsivity of central and peripheral catecholaminergic systems and impairment of the hypothalamic-pituitary-adrenal axis

Annals of the New York Academy of Sciences
G CizzaG P Chrousos

Abstract

The effects of acute stress on various indices of sympatho-adrenal, sympathoneural functions and hypothalamic-pituitary-adrenal (HPA) axis were examined both at central and peripheral sites in healthy, intact male Fischer 344/N rats of increasing age. Extracellular fluid (ECF) levels of norepinephrine (NE), its metabolites dihydroxyphenylglycol (DHPG), and methoxyhydroxyphenylglycol (MHPG), and of the dopamine metabolite dihydroxyphenylacetic acid (DOPAC), were measured 24 h after implantation of a microdialysis probe in the paraventricular nucleus (PVN) of the hypothalamus, and samples collected at 30-min. intervals during immobilization (IMMO). ECF levels of NE, DHPG, MHPG, and DOPAC were at baseline similar in both age groups, and all increased significantly in response to IMMO. The IMMO-induced increases in ECF levels of NE and MHPG were, however, significantly smaller in old than in young rats. Plasma levels of the dihydroxyphenylalanine (DOPA), -NE, epinephrine (EPI), DHPG, MHPG, dopamine (DA), DOPAC and HVA, were determined in different groups of young and old rats, cannulated in the tail artery, at baseline, and after 5, 30, 60, and 120 min of IMMO. Basal levels of DOPA, DHPG, MHPG, DA, DOPAC, HVA, NE and EPI were signi...Continue Reading

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Citations

Jul 4, 2012·The Journal of Physiological Sciences : JPS·Tetsuya MatsuuraMitsuyuki Ichinose
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·John A StanfordGreg A Gerhardt
Jan 24, 2002·Neurobiology of Aging·Abdeladim ElhamdaniCristina R Artalejo
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Sep 8, 2012·The Journal of Endocrinology·Branka Sosic-JurjevicJosef Köhrle
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Aug 30, 2008·Physiology & Behavior·Tracy M SegarJames P Herman
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Jan 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Susan H McKiernanJudd Aiken
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Nov 28, 2001·Journal of Neuroendocrinology·T KanedaK Hashimoto
Jul 14, 2020·Journal of Agricultural and Food Chemistry·Marko MilerVerica Milošević

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