PMID: 9539307Apr 16, 1998Paper

Aging is associated with changes in allopregnanolone concentrations in brain, endocrine glands and serum in male rats

European Journal of Endocrinology
Francesca BernardiAndrea R Genazzani

Abstract

Allopregnanolone is a potent neuroactive steroid hormone produced in the brain and in peripheral endocrine glands. The present study investigated possible age-related variations in allopregnanolone content in brain areas, endocrine glands and serum of male rats. Wistar male rats were categorized into 5 groups (6 rats in each) according to age: 6, 12, 16, 18 and 20 months respectively. Allopregnanolone content in acidic homogenates of brain cortex, hypothalamus, pituitary, adrenals and gonads was measured by a specific radioimmunoassay. Serum allopregnanolone, corticosterone and testosterone were also assayed by radioimmunoassay. Brain cortex allopregnanolone content decreased significantly with age, while hypothalamic allopregnanolone content remained constant until 18 months and increased significantly at 20 months. Pituitary content showed a significant age-related reduction. Adrenal allopregnanolone content remained constant until 18 months, and was significantly higher at 20 months. Testis and serum allopregnanolone contents showed significant age-related increases. Serum testosterone levels showed an age-related decrease, while no age-related variation in serum corticosterone was found. The present study showed a significa...Continue Reading

Citations

Oct 6, 2000·Brain Research. Developmental Brain Research·S PetratosD W Walker
Jul 19, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B PredieriL Iughetti
Jun 29, 2006·Biology of the Neonate·Saraid S BilliardsJonathan J Hirst
Nov 20, 2002·Pediatric Research·Saraid S BilliardsJonathan J Hirst
Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kazuhiro TokudaCharles F Zorumski
Dec 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kazuhiro TokudaCharles F Zorumski
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ioannis CharalampopoulosAchille Gravanis
Aug 28, 2004·The Journal of Physiology·Phuong N NguyenJonathan J Hirst
Dec 19, 2008·The Journal of Sexual Medicine·Nicola PluchinoAndrea Riccardo Genazzani
Apr 23, 2009·The Journal of Steroid Biochemistry and Molecular Biology·E LenziA R Genazzani
Jun 9, 2009·Contraception·Nicola PluchinoAndrea Riccardo Genazzani
Apr 19, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Elena LenziAndrea Riccardo Genazzani
Oct 13, 2007·Brain Research Reviews·Jun Ming WangRoberta Diaz Brinton
May 29, 2007·Fertility and Sterility·Nicola PluchinoAndrea Riccardo Genazzani
Dec 29, 2006·Annals of the New York Academy of Sciences·Ioannis CharalampopoulosAchille Gravanis
Dec 4, 2008·The Journal of Comparative Neurology·Di WuAndrea C Gore
Dec 8, 2004·Experimental Gerontology·M ValléeW Mayo
Mar 20, 2015·Neural Regeneration Research·Mariana Rey, Héctor Coirini
Oct 18, 2014·Journal of Molecular Neuroscience : MN·Gönül GürolAyşe Karson
Feb 24, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·F BernardiA R Genazzani
Nov 1, 2006·Menopause : the Journal of the North American Menopause Society·Andrea Riccardo GenazzaniMichele Luisi
Apr 12, 2006·Menopause : the Journal of the North American Menopause Society·Andrea R GenazzaniHelenius J Kloosterboer
Sep 15, 2006·Journal of Neurophysiology·Yuri B SaalmannMike B Calford
May 15, 2013·The Journal of Pharmacology and Experimental Therapeutics·Xin WuDoodipala Samba Reddy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.