Aging, Male Sex, Obesity, and Metabolic Inflammation Create the Perfect Storm for COVID-19.

Diabetes
Franck Mauvais-Jarvis

Abstract

Coronavirus disease 2019 (COVID-19) is a novel threat that seems to result from the collusion between a new pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and an existing pandemic of metabolic disease driven by obesity. This Perspective explores the evolving epidemiological, clinical, biological, and molecular evidence to propose an unfolding paradigm in which old age, chronic metabolic disease (such as obesity, type 2 diabetes, and metabolic syndrome), and male biological sex produce a deadly symbiosis of dysregulated immunometabolism and chronic systemic inflammation that intensifies virally induced hyperinflammation associated with SARS-CoV-2 infection. It is intended to inspire new research directions and stimulate funding in this field.

References

May 8, 1997·Nature·F ZhangR W Schevitz
Jul 27, 2000·Annals of the New York Academy of Sciences·C FranceschiG De Benedictis
Jan 31, 2002·Arthritis and Rheumatism·George MoxleyMichael C Neale
Jan 27, 2004·American Journal of Epidemiology·J KarlbergW Y Y Lai
May 4, 2004·Nature Reviews. Immunology·Antonio La Cava, Giuseppe Matarese
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Nicole Cossrow, Bonita Falkner
Jan 6, 2006·Journal of Atherosclerosis and Thrombosis·Paul ZimmetJonathan Shaw
Apr 14, 2006·Emerging Infectious Diseases·Jeffery K Taubenberger, David M Morens
Oct 26, 2006·Obesity·Patricia BlackburnCharles Couillard
Jan 4, 2007·The Journal of Clinical Investigation·Carey N LumengAlan R Saltiel
Feb 9, 2010·PLoS Pathogens·Saskia L SmitsBart L Haagmans
Feb 17, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K L GroveD J Clegg
May 7, 2014·Diabetes Research and Clinical Practice·Nathalie EsserNicolas Paquot
Nov 5, 2014·The Journal of Experimental Medicine·Annie MirsoianWilliam J Murphy
Jun 28, 2016·JCI Insight·Niki D J UbagsBenjamin T Suratt
Jul 7, 2016·Immunotherapy·Toshio TanakaTadamitsu Kishimoto
Aug 23, 2016·Nature Reviews. Immunology·Sabra L Klein, Katie L Flanagan
Dec 19, 2016·American Journal of Preventive Medicine·Irena StepanikovaGabriela R Oates
Jan 4, 2017·The Journal of Clinical Investigation·Alan R Saltiel, Jerrold M Olefsky
Jan 4, 2017·The Journal of Clinical Investigation·Daniel A WinerTony K T Lam
Apr 5, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rudragouda ChannappanavarStanley Perlman
May 31, 2017·Seminars in Immunopathology·Benjamin G ChoustermanGeorg F Weber
Dec 11, 2017·Advances in Experimental Medicine and Biology·Kalypso Karastergiou, Susan K Fried
Jul 31, 2018·Current Diabetes Reports·Eric ChangKanakadurga Singer
Apr 29, 2019·Allergology International : Official Journal of the Japanese Society of Allergology·Kaoru WatanabeKen Ohta
Feb 28, 2020·Nature·Ajithkumar VasanthakumarAxel Kallies
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 19, 2020·The New England Journal of Medicine·Xiaoxia LuUNKNOWN Chinese Pediatric Novel Coronavirus Study Team
Mar 21, 2020·Lancet·Puja MehtaUNKNOWN HLH Across Speciality Collaboration, UK
Mar 28, 2020·MMWR. Morbidity and Mortality Weekly Report·UNKNOWN CDC COVID-19 Response Team
Mar 29, 2020·The Journal of Clinical Investigation·Guang ChenQin Ning
Apr 1, 2020·The New England Journal of Medicine·Pavan K BhatrajuCarmen Mikacenic
Apr 2, 2020·Diabetes/metabolism Research and Reviews·Weina GuoDesheng Hu
Apr 8, 2020·Journal of Medical Virology·Pan LuoJuan Li
Apr 8, 2020·Osong Public Health and Research Perspectives·UNKNOWN COVID-19 National Emergency Response Center, Epidemiology and Case Management Team, Korea Centers for Disease Control and Pr
Apr 10, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jennifer LighterAnna Stachel

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Citations

Nov 25, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Bruno HalpernOscar H Franco
Nov 28, 2020·Future Oncology·Angioletta LasagnaPaolo Pedrazzoli
Jan 5, 2021·Immunity & Ageing : I & a·Sameer MohammadAbderrezak Bouchama
Jan 12, 2021·Journal of Proteome Research·Shalini AggarwalSanjeeva Srivastava
Feb 2, 2021·Frontiers in Endocrinology·Andrew B CrouseAnath Shalev
Feb 13, 2021·Vaccines·Jorge Pérez-GalarzaLucy Baldeón
Nov 8, 2020·Pathogens·Akshay KanakanRajesh Pandey
Jan 1, 2021·The Chinese Journal of Physiology·Yu-Hsiu ChangPo-Shiuan Hsieh
Dec 29, 2020·Signal Transduction and Targeted Therapy·Hong-Yi ZhengYong-Tang Zheng
Jan 30, 2021·Frontiers in Aging Neuroscience·Riya Ganji, P Hemachandra Reddy
Nov 7, 2020·Journal of the American Society of Nephrology : JASN·Johan De MeesterUNKNOWN NBVN Kidney Registry Group
Feb 7, 2021·Biology of Sex Differences·Yilin YoshidaFranck Mauvais-Jarvis
Nov 11, 2020·Biochemical and Biophysical Research Communications·Dylan C Sarver, G William Wong
Mar 30, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Livia Costa de OliveiraSimone Garruth Dos Santos Machado Sampaio
Nov 11, 2020·Experimental Gerontology·Daniel J Moreno Fernández-AyalaGuillermo López-Lluch
Apr 17, 2021·European Journal of Internal Medicine·M F LandechoGema Frühbeck
Apr 29, 2021·Vascular Health and Risk Management·Mashael K AlshaikhMohammed Aljuaid
May 7, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Arcelia Guerson-GilLawrence J Brandt
May 25, 2021·Journal of Primary Care & Community Health·Sanjeev NandaIvana T Croghan
May 27, 2021·Journal of Endocrinological Investigation·R S AuriemmaA Colao
Jun 3, 2021·International Journal of Molecular Sciences·Noha Mousaad ElemamNabil Sulaiman
Jun 7, 2021·Journal of Science and Medicine in Sport·Francis Ribeiro de SouzaMarcelo Rodrigues Dos Santos
Jun 2, 2021·Journal of Medical Virology·Shireen NigarM Anwar Hossain
Jun 15, 2021·Molecular Omics·Vivian TountaGerald Larrouy-Maumus
Feb 4, 2021·Aging and Disease·Shu LiYaogang Wang
Jun 18, 2021·The Journal of Clinical Endocrinology and Metabolism·Jamie WhiteJanine Clayton
Aug 6, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Dong-Hyuk ChoJun Gyo Gwon
Aug 11, 2021·Aging·Vivekananda BudamaguntaDaohong Zhou
Aug 13, 2021·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Ibrahim SahinAlper Sonmez

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