PMID: 109542Jul 1, 1979

Aging model for unexposed human dermis

The Journal of Investigative Dermatology
K S Carlisle, W Montagna

Abstract

Young human dermis is charterized by the presence of many fibroblasts with distended endoplasmic reticulum, extensive Golgi bodies, and orderly and "clean"-appearing groundwork. Older dermis contains inactive fibrocytes with lipofuscin-like granules, macrophages with dense granules, and extracellular spaces with evidence of degeneration. We have found the sex skin of cycling pigtail macaques (Macaca nemestrina) a predictable model for studies on aging changes in human dermis. Swollen sex skin has many biochemical and ultrastructural properties that are similar to those of young dermis, and deflated sex skin resembles older human skin. Sex skin, however, is unique in that it becomes "rejuvenated" with each succeeding ovarian cycle. This animal model may prove useful to researchers attempting to increase their understanding of aging in connective tissue.

Citations

Nov 15, 1984·Postgraduate Medicine·W F Larrabee, I Caro
Nov 28, 1981·British Medical Journal·J A Savin

Related Concepts

Senility
Anthropoidea
Estrus
Extracellular Space
Fibroblasts
Accessory Sex Organs, Female
Macaca
Macrophage
Skin
Skin Physiological Phenomena

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