Aging of Brown and Beige/Brite Adipose Tissue

Handbook of Experimental Pharmacology
Antonia GrajaTim J Schulz

Abstract

Brown adipose tissue aging and the concomitant loss of thermogenic capacity have been linked to an inability to maintain normal energy homeostasis in late life. Similarly, the ability of white fat to convert into brite/beige adipose tissue declines. This may ultimately exacerbate the progression of age-related metabolic pathologies, such as insulin resistance and obesity. The depletion of all types of brown adipocytes during aging is well-established and has been described in rodent models as well as humans. We here review the available literature on the potential mechanisms leading to cell-autonomous and microenvironment-related aspects of brown adipocyte dysfunction. Among these, cellular senescence, mitochondrial impairment, and deteriorating changes to the local and endocrine microenvironments have been proposed. An important goal of aging research is to develop approaches that may not only extend life expectancy but also prolong health-span. These efforts may also be aimed at maintaining metabolic health throughout life by targeting brown adipocyte function.

Citations

Jun 17, 2020·Ageing Research Reviews·Alexander Fedintsev, Alexey Moskalev
May 23, 2020·Molecular and Cellular Endocrinology·Isabel ReinischAndreas Prokesch
Dec 18, 2019·Metabolism: Clinical and Experimental·Ariana Vargas-CastilloArmando R Tovar
Aug 29, 2021·Biochemical and Biophysical Research Communications·Dong LiShuxia Wang
Sep 3, 2021·Mechanisms of Ageing and Development·Mita VargheseKanakadurga Singer
Sep 8, 2021·Nature Communications·Adela UrisarriMiguel López

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Related Papers

Best Practice & Research. Clinical Endocrinology & Metabolism
Gema Medina-Gómez
Molecular and Cellular Endocrinology
Marta GiraltFrancesc Villarroya
Cold Spring Harbor Perspectives in Biology
Kelesha Sarjeant, Jacqueline M Stephens
© 2022 Meta ULC. All rights reserved