Aging of cerebellar Purkinje cells

Cell and Tissue Research
Changzheng ZhangTianmiao Hua

Abstract

Cerebellar Purkinje cells (PCs), the sole output neurons in the cerebellar cortex, play an important role in the cerebellar circuit. PCs appear to be rather sensitive to aging, exhibiting significant changes in both morphology and function during senescence. This article reviews such changes during the normal aging process, including a decrease in the quantity of cells, atrophy in the soma, retraction in the dendritic arborizations, degeneration in the subcellular organelles, a decline in synapse density, disorder in the neurotransmitter system, and alterations in electrophysiological properties. Although these deteriorative changes occur during aging, compensatory mechanisms exist to counteract the impairments in the aging PCs. The possible neural mechanisms underlying these changes and potential preventive treatments are discussed.

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Citations

Jan 25, 2012·Obstetrics and Gynecology International·Paul R Brezina, Yulian Zhao
Apr 17, 2012·Journal of Aging Research·Siân RobinsonAvan Aihie Sayer
Nov 9, 2014·Brain Structure & Function·Emmanuel P GilissenJean-Pierre Brion
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Oct 25, 2016·Neurobiology of Aging·Mélissa Lessard-BeaudoinRona K Graham
Jun 20, 2019·Journal of Neurophysiology·Michael C Schubert, Americo A Migliaccio
Jul 3, 2021·International Journal of Molecular Sciences·Elisa RodaPaola Rossi
May 22, 2017·Neurochemistry International·Tatsuya YamadaHiromi Sesaki

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