PMID: 109543Jul 1, 1979

Aging of melanocytes

The Journal of Investigative Dermatology
F Hu


Choroidal melanocytes of the eyes of postnatal animals are classified as postmitotic terminally differentiated cells. They have specific granules, the melanosomes, which undergo changes qualitatively and quantitatively correlated to the animal's increasing age. Epidermal melanocytes, which normally divide only on demand or by stimulation, are classified as intermittent mitotic cells. During their development, lentigines and nevi of the skin show progressive ultrastructural and cytochemical changes similar to those in the choroidal cells, and thus may be considered as aging populations of skin melanocytes. These facts have led to the conclusion that choroidal melanocytes may be used advantageously as a model for studying changes in cells from maturation to senescence.


Oct 1, 1990·The Journal of Dermatologic Surgery and Oncology·R S Kurban, J Bhawan
May 22, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Doina IvanVictor G Prieto
Oct 1, 1996·The American Journal of Dermatopathology·Z B ArgenyiM Wick
Jul 9, 2002·Pigment Cell Research·D C Bennett, Estela E Medrano
Apr 1, 1990·The British Journal of Dermatology·W Montagna, K Carlisle
Mar 1, 1991·Pigment Cell Research·A S BreathnachM Picardo
Mar 1, 1987·Journal of Periodontal Research·C A Hedin, A Larsson

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