Aging of myelinating glial cells predominantly affects lipid metabolism and immune response pathways

Glia
Valérie VerdierRoman Chrast

Abstract

Both the central and the peripheral nervous systems are prone to multiple age-dependent neurological deficits, often attributed to still unknown alterations in the function of myelinating glia. To uncover the biological processes affected in glial cells by aging, we analyzed gene expression of the Schwann cell-rich mouse sciatic nerve at 17 time points throughout life, from day of birth until senescence. By combining these data with the gene expression data of myelin mouse mutants carrying deletions of either Pmp22, SCAP, or Lpin1, we found that the majority of age-related transcripts were also affected in myelin mutants (54.4%) and were regulated during PNS development (59.5%), indicating a high level of overlap in implicated molecular pathways. The expression profiles in aging copied the direction of transcriptional changes observed in neuropathy models; however, they had the opposite direction when compared with PNS development. The most significantly altered biological processes in aging involved the inflammatory/immune response and lipid metabolism. Interestingly, both these pathways were comparably changed in the aging optic nerve, suggesting that similar biological processes are affected in aging of glia-rich parts of th...Continue Reading

References

May 1, 1994·Experimental Neurology·M Kowalska, J F Disterhoft
Jan 14, 2000·Journal of Anatomy·D CeballosX Navarro
Jul 2, 2002·Journal of Anatomy·Mathias MäurerRudolf Martini
Sep 16, 2003·Statistics in Medicine·Vito M R Muggeo
Oct 3, 2003·Genes & Development·Mark H G VerheijenGreg Lemke
Sep 10, 2004·The Journal of the American Board of Family Practice·James W MoldMichelle Roberts
Oct 6, 2004·Genome Biology·Robert C GentlemanJianhua Zhang
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Gordon K Smyth
Sep 14, 2006·Current Opinion in Neurology·Gerd Meyer Zu Hörste, Klaus-Armin Nave
Nov 28, 2006·Bioinformatics·Zhen Jiang, Robert Gentleman
Apr 4, 2007·Neurochemical Research·Stacey L Thomas, George H De Vries
Jul 17, 2007·Molecular and Cellular Neurosciences·Anne-Sophie de PreuxRoman Chrast
Jan 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John D CahoyBen A Barres
Jan 8, 2008·Nucleic Acids Research·Simon M LinWarren A Kibbe
Jan 25, 2008·Annals of Human Genetics·N BarisicV Timmerman
May 10, 2008·Bioinformatics·Pan DuSimon M Lin
Jun 19, 2008·Genes & Development·Karim NadraRoman Chrast
Jan 16, 2009·The FEBS Journal·Nutabi CamargoMark H G Verheijen
May 15, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gesine SaherKlaus-Armin Nave
Oct 17, 2009·Molecular Immunology·Valeria RamagliaFrank Baas
Nov 12, 2009·BMC Bioinformatics·Wei ShiGordon K Smyth
Dec 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mark H G VerheijenAugust B Smit
May 12, 2010·The Journal of Cell Biology·Markus FinzschMichael Wegner
Nov 11, 2010·Journal of Lipid Research·Roman ChrastMark H G Verheijen
Nov 12, 2010·Nature·Klaus-Armin Nave

❮ Previous
Next ❯

Citations

Jan 8, 2013·Molecular Syndromology·H AzzedineR Chrast
Jun 20, 2013·Human Molecular Genetics·Hamid AzzedineRoman Chrast
Dec 6, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Michael E WalshHolly Van Remmen
Apr 1, 2016·Journal of Neuropathology and Experimental Neurology·Vidya S KrishnanMiranda D Grounds
Apr 23, 2015·The European Journal of Neuroscience·Luca BartesaghiRoman Chrast
Feb 24, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Barbara B RaddatzReiner Ulrich
Nov 29, 2016·Journal of Neurochemistry·José F Rodríguez-MolinaJohn Svaren
Apr 5, 2019·Annals of Neurology·John SvarenMichael E Shy
May 2, 2020·Human Molecular Genetics·Harrison PanteraJohn Svaren
Jun 4, 2019·Lipids in Health and Disease·Jiangquan YangZhenglong Ge

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.