PMID: 15374444Mar 1, 1991Paper

Aging of the liver: facts and theories

Archives of Gerontology and Geriatrics
Kenichi Kitani

Abstract

Although most theories of aging assume that cellular functions decline with aging, many intracellular functions in the liver, such as enzyme activities, stay fairly stable in old age. This does not appear to be an antifact caused by in vitro experimental design, since in vivo pharmacokinetic data also demonstrate that most, if not all, biotransformation capacities of the liver remain stable during the aging process, if we take the decline in liver volume with age into account. Thus, many theories to explain the decline in cellular functions during aging appear to be based on erroneous assumptions. The stability of cellular function in old age does not necessarily mean, however, that all cellular functions are identical for young and old organisms. Once unfavorable conditions, such as malnutrition, infection, etc., are involved, the response of the liver is quite different for young and old subjects, demonstrating a more efficient and versatile response in young animal livers in comparison to old livers. Large differences in enzyme activities between young and old organisms appear during stress and especially during recovery from stress. Accordingly, any aging theory needs to explain a potential difference in liver functions (su...Continue Reading

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Citations

Apr 1, 1992·Gastroenterologia Japonica·K Kitani
Dec 20, 2012·Current Gastroenterology Reports·Jonathan G StineJames H Lewis
Sep 1, 1994·Archives of Gerontology and Geriatrics·K Kitani
Feb 7, 2004·Archives of Gerontology and Geriatrics·Imre Zs-Nagy
Dec 22, 1999·Neurobiology of Aging·J Victoroff
Nov 22, 2007·Aging Cell·Bernd Moosmann, Christian Behl
Apr 27, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·A SanzJ M Tierno de Figueroa

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