Aging of the vascular wall: serum concentration of elastin peptides and elastase inhibitors in relation to cardiovascular risk factors. The EVA study

Atherosclerosis
L BizbizL Robert

Abstract

The relations of biological markers of extracellular matrix (plasma elastin peptides and elastase inhibitors) to the clinical history of cardiovascular diseases and risk factors for atherosclerosis were examined in a large population study (the EVA Study) on vascular and cognitive aging performed in 1389 men and women aged 59-71 years. A moderate decrease in elastin peptides was observed in women with a self-reported history of coronary heart disease (P < 0.091) and stroke (P < 0.03) as well as with diabetes (P < 0.043). Similar but non-significant trends were found in men. Furthermore, elastin peptides were significantly and positively correlated to HDL-cholesterol and apolipoprotein A1 in both sexes. On the other hand, elastase inhibitor titers were significantly higher in women than in men. A moderate increase was also found in men (P < 0.097) and women (P < 0.068) with a history of coronary heart disease that reached significance level after pooling both sexes (P < 0.014). Furthermore, elastase inhibitor titers were significantly and positively related to fibrinogen and C reactive protein in either sex. No consistent associations were observed between both biological markers of extracellular matrix and age, blood pressure, ...Continue Reading

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Citations

Apr 5, 2000·Pathology Oncology Research : POR·R Ladislas
Feb 20, 2009·Aging Clinical and Experimental Research·Leszek PaczekIrena Bartlomiejczyk
Feb 17, 2010·Biogerontology·L RobertA M Robert
Nov 19, 2003·Pathologie-biologie·L Robert, A M Robert
Dec 23, 1998·Atherosclerosis·L RobertB Jacotot
Nov 25, 2000·Archives of Gerontology and Geriatrics·J Labat-RobertL Robert
Jul 26, 2008·Archives of Gerontology and Geriatrics·L BizbizUNKNOWN EVA-group
Dec 10, 2002·Pathologie-biologie·Ladislas Robert
Dec 18, 1998·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G Péterszegi, L Robert
Feb 13, 2014·Cardiovascular Research·Emilio Hirsch, Alessandra Ghigo
Dec 21, 2013·Cardiovascular Research·Stephanie GayralMuriel Laffargue
Jun 13, 2013·Journal of Cardiovascular Medicine·Hiroyuki YamanakaMasahiko Katayama
Mar 22, 2014·Pathologie-biologie·J Labat-Robert, L Robert
Sep 10, 2014·Pathologie-biologie·L Robert, J Labat-Robert
Apr 13, 2000·Connective Tissue Research·L Robert
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Aug 9, 2005·Pathologie-biologie·Ladislas Robert
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Oct 25, 2016·The American Journal of Cardiology·Koichi AkutsuWataru Shimizu
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Jul 12, 2019·Matrix Biology : Journal of the International Society for Matrix Biology·Aurélie Le PageTamas Fulop

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