Aging-related alterations in the distribution of Ca(2+)-dependent PKC isoforms in rabbit hippocampus

Hippocampus
E A Van der ZeeJ F Disterhoft

Abstract

The immunocytochemical and subcellular localization of the Ca(2+)-dependent protein kinase C (cPKC) isoforms (PKCalpha, beta1, beta2, and gamma) was examined in rabbit hippocampus of young (3 months of age; n = 11) and aging (36 months of age; n = 14) subjects. Detailed immunocytochemical analyses revealed a significant increase in PKCbeta1, beta2, and gamma immunoreactivity in principal cell bodies and associated dendrites, and interneurons of the hilar region in the aging rabbits. The number of PKCalpha- and gamma-positive interneurons in the aging stratum oriens declined significantly. PKCalpha was least affected in principal cells, showing an increase in immunostaining in granule cells only. Weakly PKC-positive principal cells intermingled between densely stained ones were seen in parts of the hippocampus in most of the aging rabbits, showing that the degree of aging-related alterations in PKC-immunoreactivity varies between neurons. Changes in PKC expression in the molecular and subgranular layer of the aging dentate gyrus suggested a reorganization of PKC-positive afferents to this region. Western blot analysis revealed a significant loss of PKC in the pellet fraction for all isoforms, and a tendency for increased levels ...Continue Reading

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Citations

Jul 8, 2014·Neuroscience and Biobehavioral Reviews·Eddy A van der Zee
Apr 3, 2013·Neurobiology of Disease·Jarin HongpaisanDaniel L Alkon
Sep 1, 2006·Trends in Neurosciences·John F Disterhoft, M Matthew Oh
Feb 7, 2006·Progress in Neurobiology·Ella H SklanHermona Soreq
Sep 22, 2015·Frontiers in Aging Neuroscience·Andrew T Kempsell, Lynne A Fieber
Jun 16, 2009·Neurobiology of Aging·Cheng B LuMartin Vreugdenhil
May 19, 2012·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Yin ShiYing-Ying Zhang
Jul 25, 2019·International Journal of Molecular Sciences·Donatella PastoreDavid Della-Morte
Feb 8, 2019·Frontiers in Pharmacology·Sara BaratchiPeter McIntyre

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