PMID: 30146508Aug 28, 2018Paper

Aging-related frailty and sarcopenia. Frailty/sarcopenia and insulin/IGF-1 signaling

Clinical calcium
Takayoshi Sasako, Kohjiro Ueki

Abstract

Insulin and IGF-1 share many of the downstream molecules involved in the signal transduction, and cooperatively maintain volume of skeletal muscle. Along with aging, however, insulin/IGF-1 signaling is impaired, mainly due to insulin resistance and lowered IGF-1 levels, which is thought to promote the development of sarcopenia, and thus they are among the promising therapeutic targets. It is also known that sarcopenia is associated with the development of frailty, one of the phenomena of systemic aging. Actually insulin/IGF-1 signaling is known to affect longevity in lower organisms, but in humans, little is known about roles of the signaling in the development of frailty, and further investigation is needed.

Related Concepts

Related Feeds

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Related Papers

Archivos de bronconeumología
Leocadio Rodríguez Mañas, Isabel Rodríguez Sánchez
Journal of Musculoskeletal & Neuronal Interactions
D D Thompson
© 2022 Meta ULC. All rights reserved