PMID: 9191077Jun 1, 1997Paper

Aging-related regulation of myo-inositol 1,4,5-trisphosphate signal transduction pathway in the rat striatum

Brain Research. Molecular Brain Research
O J Igwe, M B Filla

Abstract

To determine the effects of the aging process on the regulation of phosphoinositide signal transduction pathway, inositol 1,4,5-trisphosphate and inositol 1,4,5-trisphosphate receptor-associated parameters were examined in the striatum of brains removed from young (3 months), adult (12 months) and senescent (25 months) male Fischer 344 rats. Inositol 1,4,5-trisphosphate content was significantly increased (P < or = 0.01) at 25 months of age compared to 3 and 12 months. No age-related differences in phosphatidylinositol 4,5-bisphosphate hydrolysis were found in striatal slices after stimulation with trans-(1S,3R)-1-aminocyclopentane-1,3-dicarboxylate, a metabotropic glutamatergic receptor agonist. Phosphatidylinositol 4,5-bisphosphate hydrolysis following stimulation with (R,S)-alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid, a glutamatergic/quisqualate agonist, showed a significantly increased accumulation of net [3H]inositol 1,4,5-trisphosphate in senescent striatum whereas the muscarinic cholinergic agonist carbachol induced highest response in the young striatum. In each case, agonist-stimulated response was significantly reduced in the presence of the receptor-associated antagonist. The density of inositol 1,4,5-t...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jun 1, 1992·Journal of Neurochemistry·J JollesR Ravid
Apr 30, 1992·Biochemical and Biophysical Research Communications·T A LinG Y Sun
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L PrezeauJ Bockaert
Aug 28, 1992·Science·E R Stadtman
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C A RossA Ullrich
May 1, 1991·Trends in Pharmacological Sciences·C Erneux, K Takazawa
Dec 1, 1991·Aging : Clinical and Experimental Research·J A JosephG S Roth
Dec 1, 1988·Trends in Neurosciences·D A Eberhard, R W Holz
Nov 1, 1989·Trends in Neurosciences·E Melloni, S Pontremoli
Mar 31, 1989·Biochemical and Biophysical Research Communications·D S BredtS H Snyder
Apr 1, 1989·Trends in Pharmacological Sciences·S R Nahorski, B V Potter
Dec 1, 1989·Analytical Biochemistry·N M Dean, M A Beaven
Feb 1, 1988·Archives of Biochemistry and Biophysics·K K WangB D Roufogalis
Mar 1, 1988·Cellular and Molecular Neurobiology·S H SnyderJ M Baraban
Nov 22, 1988·Neuroscience Letters·L T YoungJ J Warsh
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S WeissJ Bockaert
Jul 1, 1987·Neurobiology of Aging·G E Gibson, C Peterson
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Aug 1, 1983·Computer Programs in Biomedicine·G A McPherson
Aug 29, 1983·Biochimica Et Biophysica Acta·C E StokesJ N Hawthorne
Oct 1, 1993·Brain Research. Molecular Brain Research·O J Igwe
Nov 1, 1994·Trends in Pharmacological Sciences·K K Wang, P W Yuen

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Citations

Apr 3, 2003·Experimental Gerontology·Nataliya S KavokNataliya A Babenko
Oct 26, 2002·Free Radical Biology & Medicine·Véronique MonnierHervé Tricoire
Dec 13, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthew B Bevers, Robert W Neumar
Mar 23, 2011·Journal of Aging Research·Jean-Paul DecuypereGeert Bultynck
Mar 19, 2009·Child and Adolescent Psychiatry and Mental Health·Rohan G MaharajShamin Renwick
Apr 7, 2020·Reviews in the Neurosciences·Diana Marcela Cuestas Torres, Fernando P Cardenas
Jan 5, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A H HassanO F Almeida
Jun 6, 2007·Molecular and Cellular Biochemistry·P KaplanO Krizanova
Aug 11, 2018·Frontiers in Physiology·Ali H EidHaissam Abou-Saleh

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