Aging-related systemic manifestations in COPD patients and cigarette smokers

PloS One
Laurent BoyerSerge Adnot

Abstract

Chronic obstructive pulmonary disease (COPD) is often associated with age-related systemic abnormalities that adversely affect the prognosis. Whether these manifestations are linked to the lung alterations or are independent complications of smoking remains unclear. To look for aging-related systemic manifestations and telomere shortening in COPD patients and smokers with minor lung destruction responsible for a decline in the diffusing capacity for carbon monoxide (DLCO) corrected for alveolar volume (KCO). Cross-sectional study in 301 individuals (100 with COPD, 100 smokers without COPD, and 101 nonsmokers without COPD). Compared to control smokers, patients with COPD had higher aortic pulse-wave velocity (PWV), lower bone mineral density (BMD) and appendicular skeletal muscle mass index (ASMMI), and shorter telomere length (TL). Insulin resistance (HOMA-IR) and glomerular filtration rate (GFR) were similar between control smokers and COPD patients. Smokers did not differ from nonsmokers for any of these parameters. However, smokers with normal spirometry but low KCO had lower ASMMI values compared to those with normal KCO. Moreover, female smokers with low KCO, had lower BMD and shorter TL compared to those with normal KCO. ...Continue Reading

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Citations

Sep 16, 2015·Current Opinion in Clinical Nutrition and Metabolic Care·Jeroen P KoomanPeter Stenvinkel
Jun 23, 2015·Pharmacology & Therapeutics·Serge AdnotJorge Boczkowski
Aug 20, 2016·QJM : Monthly Journal of the Association of Physicians·C YeK Nasir
Feb 7, 2018·Cell Death & Disease·Frédéric SchlemmerJorge Boczkowski
May 4, 2016·Expert Review of Respiratory Medicine·Nicolas Roche
Sep 14, 2016·Journal of Bone Metabolism·Ryo OkazakiDaisuke Inoue
May 11, 2016·Annals of the American Thoracic Society·Laurent BoyerSerge Adnot
Mar 30, 2019·Journal of Korean Medical Science·Eun-Jung KimYunsun Jung
Apr 25, 2019·Journal of Clinical Medicine·Filip J J TriestLowie E G W Vanfleteren
Jun 15, 2018·Scientific Reports·Kahkashan RashidIrfan Rahman
Mar 15, 2019·Journal of Cardiopulmonary Rehabilitation and Prevention·Jéssica FonsecaFabio Pitta
Apr 30, 2021·Néphrologie & thérapeutique·Camille Cohen
May 18, 2021·Mechanisms of Ageing and Development·Juliana Ruiz FernandesGil Benard

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