Aging-related trajectories of lung function in the general population-The Doetinchem Cohort Study

PloS One
Sandra H van OostromH Susan J Picavet

Abstract

The objective of this study was to explore trajectories of lung function decline with age in the general population, and to study the effect of sociodemographic and life style related risk factors, in particular smoking and BMI. For this purpose, we used data from the Doetinchem Cohort Study (DCS) of men and women, selected randomly from the general population and aged 20-59 years at inclusion in 1987-1991, and followed until the present. Participants in the DCS are assessed every five years. Spirometry has been performed as part of this assessment from 1994 onwards. Participants were included in this study if spirometric measurement of FEV1, which in this study was the main parameter of interest, was acceptable and reproducible on at least one measurement round, leading to the inclusion of 5727 individuals (3008 females). Statistical analysis revealed three typical trajectories. The majority of participants followed a trajectory that closely adhered to the Global Lung Initiative Reference values (94.9% of men and 96.4% of women). Two other trajectories showed a more pronounced decline. Smoking and the presence of respiratory complaints were the best predictors of a trajectory with stronger decline. A greater BMI over the follo...Continue Reading

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Citations

Apr 27, 2019·Environmental Health : a Global Access Science Source·Edith B MilanziUlrike Gehring
Jun 5, 2019·Chronic Respiratory Disease·Camilla Boslev BaarnesCharlotte Suppli Ulrik
Feb 12, 2020·Scientific Reports·Kristoffer L NorheimPascal Madeleine
Oct 9, 2019·Aging and Disease·Tatiana Rafaela Lemos LimaAgnaldo José Lopes
Sep 8, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Daniel O OkyereShyamali C Dharmage

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Software Mentioned

lcmm
R package lme4
R
SAS

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