PMID: 9535055Apr 16, 1998Paper

Aging results in attenuated gonadotropin releasing hormone-luteinizing hormone axis responsiveness to glutamate receptor agonist N-methyl-D-aspartate

Journal of Neuroendocrinology
J J BonaveraC Wang

Abstract

Reproductive aging in the Brown Norway rat occurs because of testicular as well as hypothalamic-pituitary dysfunction. Excitatory amino acids (EAA) participate in the regulation of pulsatile secretion of hypothalamic GnRH and pituitary LH. In the present study, we studied the EAA-GnRH-LH axis for possible age-related alterations in prepubertal (35 days), young (3-4 months), middle-aged (12-13 months) and old (21-23 months) rats. In the first experiment, an intra-atrial cannula was implanted in rats of different ages to evaluate the pituitary response to small, physiological intravenous bolus administration of GnRH (0.5 or 1.0 nmol/100 g body weight). The results showed no age-related significant differences in in-vivo serum LH or FSH responsiveness to GnRH. In a second experiment, blood samples for the gonadotropins were withdrawn immediately before and 10 min after an iv injection of the glutamate receptor agonist N-methyl-D-aspartate (NMDA; 5 mg/kg, a dose that induces a physiological LH pulse in young rats). Administration of NMDA induced significant increases in LH and prolactin in all groups of animals (P<0.05) and a significant FSH response in young and middle-aged but not old rats. NMDA-induced LH, FSH and prolactin rele...Continue Reading

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Citations

Feb 13, 2001·Endocrine Reviews·E Terasawa, D L Fernandez
Nov 25, 2004·Endocrine Reviews·Roy G SmithYuxiang Sun
Nov 3, 2012·British Journal of Clinical Pharmacology·Marieke Liem-MoolenaarJoop M A van Gerven
May 14, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter Y LiuJohannes D Veldhuis
Feb 27, 2013·Nature Reviews. Endocrinology·Johannes D Veldhuis
Jun 29, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Amiya P Sinha HikimChristina Wang
Aug 23, 2003·Endocrinology·Tandra R ChakrabortyAndrea C Gore
Mar 4, 2006·Endocrinology·Daniel M KeenanJohannes D Veldhuis
Jun 18, 2002·Ageing Research Reviews·Kurt Heininger

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