Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice

Free Radical Biology & Medicine
Katrin SchuesselAnne Eckert

Abstract

Mutations in the presenilins (PS) account for the majority of familial Alzheimer disease (FAD) cases. To test the hypothesis that oxidative stress can underlie the deleterious effects of presenilin mutations, we analyzed lipid peroxidation products (4-hydroxynonenal (HNE) and malondialdehyde) and antioxidant defenses in brain tissue and levels of reactive oxygen species (ROS) in splenic lymphocytes from transgenic mice bearing human PS1 with the M146L mutation (PS1M146L) compared to those from mice transgenic for wild-type human PS1 (PS1wt) and nontransgenic littermate control mice. In brain tissue, HNE levels were increased only in aged (19-22 months) PS1M146L transgenic animals compared to PS1wt mice and not in young (3-4 months) or middle-aged mice (13-15 months). Similarly, in splenic lymphocytes expressing the transgenic PS1 proteins, mitochondrial and cytosolic ROS levels were elevated to 142.1 and 120.5% relative to controls only in cells from aged PS1M146L animals. Additionally, brain tissue HNE levels were positively correlated with mitochondrial ROS levels in splenic lymphocytes, indicating that oxidative stress can be detected in different tissues of PS1 transgenic mice. Antioxidant defenses (activities of antioxidan...Continue Reading

References

Apr 10, 1992·Science·J A Hardy, G A Higgins
Jan 1, 1990·Methods in Enzymology·H Esterbauer, K H Cheeseman
Jan 1, 1993·Free Radical Research Communications·R E Huie, S Padmaja
Jun 14, 1993·FEBS Letters·T DyrksK Beyreuther
Dec 1, 1995·European Journal of Immunology·M CastedoG Kroemer
Dec 1, 1995·Human Molecular Genetics·D CampionS Tardieu
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·R P ParshadJ H Robbins
Jan 1, 1997·Immunology Today·G KroemerS A Susin
Jan 1, 1997·European Journal of Immunology·P MarchettiG Kroemer
Jul 1, 1997·Brain Research. Molecular Brain Research·C CzechG Tremp
Oct 27, 1997·Neurology·R H SwerdlowW D Parker
Apr 30, 1998·Neurobiology of Aging·B WolozinJ Palacino
Aug 26, 1998·Biochimica Et Biophysica Acta·S A SusinG Kroemer
Feb 12, 2000·Progress in Neurobiology·C CzechL Pradier
Feb 22, 2000·Biological Psychiatry·P H St George-Hyslop

❮ Previous
Next ❯

Citations

Feb 26, 2009·Cellular and Molecular Neurobiology·You-Jun FuBert C Lynn
Jul 24, 2012·Molecular Neurobiology·Kristina LeunerWalter E Müller
Sep 18, 2007·Antioxidants & Redox Signaling·Kristina LeunerWalter E Müller
Nov 29, 2011·Antioxidants & Redox Signaling·Karen SchmittAnne Eckert
Apr 29, 2009·International Journal of Molecular Sciences·Rudy J CastellaniGeorge Perry
Mar 29, 2014·Oxidative Medicine and Cellular Longevity·Marco Antonio Meraz-RíosVictoria Campos-Peña
Jul 11, 2013·Oxidative Medicine and Cellular Longevity·Vega García-EscuderoJesús Avila
Nov 19, 2009·Brain Structure & Function·Gregory A ElderPatrick R Hof
Apr 7, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Luciana NasoPatricia Williams
Jul 11, 2006·Journal of Neuropathology and Experimental Neurology·Akihiko NunomuraMark A Smith
Apr 22, 2008·Free Radical Biology & Medicine·Rosa ResendeCatarina Resende Oliveira
Apr 4, 2012·Geriatrics & Gerontology International·Kalaiselvi Velayutham AnandPitchairaj Geraldine
Jan 27, 2010·The Mount Sinai Journal of Medicine, New York·Gregory A ElderRita De Gasperi
Aug 6, 2015·Food & Function·Xiao-Lin YuRui-Tian Liu
May 9, 2006·Experimental Gerontology·Susanne HauptmannWalter E Müller
Mar 19, 2009·Biochemical and Biophysical Research Communications·Gunter P Eckert, Walter E Müller
Aug 9, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yangying SunJunjiang Li
Apr 10, 2014·The Journal of Allergy and Clinical Immunology·Chisa NakashimaKenji Kabashima
Jul 3, 2013·International Journal of Biological Macromolecules·Weiqi ZhongWeiming Zhong
May 14, 2016·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Sudha GovindanJayanthi Gopalan
May 24, 2016·International Journal of Biological Macromolecules·Jing-Kun YanJian-Yong Wu
Feb 11, 2018·Cellular and Molecular Life Sciences : CMLS·Ana L Santos, Giulio Preta
Apr 19, 2008·Cell Death and Differentiation·S M JinI Mook-Jung
Mar 14, 2018·The Korean Journal of Parasitology·Dibyendu RajSandipan Ganguly
Dec 5, 2018·Food Science & Nutrition·Pan ZhaoHaiji Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis