Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells

Rejuvenation Research
Mikhail V Blagosklonny

Abstract

What is the relationship between stem cell aging and organismal aging? Does stem cell aging cause organismal aging or vice versa? Will stem cell aging aggravate age-related diseases? And what is stem cell aging? As suggested herein, hyperstimulation of signal transduction pathways can render cells compensatorily irresponsive. And the hallmark of stem cell aging is poor responsiveness to activating stimuli. On the basis of the hypothesis that insensitivity to stimuli is in part due to hyperactivation of the target of rapamycin (TOR), this article suggests a means of pharmacologic rejuvenation of stem cells and wound-healing cells.

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Citations

Aug 12, 2010·Cellular Reprogramming·Charles A EasleyGerald P Schatten
Apr 26, 2013·Current Opinion in Hematology·Hartmut Geiger, Yi Zheng
Feb 16, 2010·Expert Opinion on Emerging Drugs·James A McCubreyMelchiorre Cervello
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Dec 9, 2014·Cell Cycle·Mikhail V Blagosklonny
Dec 9, 2014·Cell Cycle·Olga V LeontievaMikhail V Blagosklonny
Feb 6, 2014·Cell Cycle·Olga V Leontieva, Mikhail V Blagosklonny
Jun 8, 2012·Cell Cycle·Tatiana V PospelovaMikhail V Blagosklonny
Apr 14, 2016·Clinical Pharmacology and Therapeutics·Johnny HuardAiping Lu
Aug 15, 2009·Integrative Cancer Therapies·Katya Chobotova
Sep 19, 2019·Interdisciplinary Sciences, Computational Life Sciences·Mohammadreza DorvashIman Tavassoly
Oct 7, 2019·Aging·Mikhail V Blagosklonny
Jun 14, 2020·Aging·Mikhail V Blagosklonny
Apr 3, 2012·Aging·Benedetta Artegiani, Federico Calegari
Aug 14, 2019·Cell Death & Disease·Mikhail V Blagosklonny
Jan 15, 2015·Aging·Olga V Leontieva, Mikhail V Blagosklonny
Feb 15, 2017·Frontiers in Physiology·Chiara de LuciaSandrine Thuret
Jan 17, 2012·Aging·Mikhail V Blagosklonny
Feb 17, 2010·Aging·Mikhail V Blagosklonny
Apr 23, 2013·Aging·Mikhail V Blagosklonny
Aug 24, 2012·Aging·Mikhail V Blagosklonny
Feb 8, 2011·Aging·Mikhail V Blagosklonny

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