Abstract
Little is known about the extent to which aging trajectories of different body systems share common sources of variance. We here present a large twin study investigating the trajectories of change in five systems: cardiovascular, respiratory, skeletal, morphometric, and metabolic. Longitudinal clinical data were collected on 3,508 female twins in the TwinsUK registry (complete pairs:740 monozygotic (MZ), 986 dizygotic (DZ), mean age at entry 48.9 ± 10.4, range 18-75 years; mean follow-up 10.2 ± 2.8 years, range 4-17.8 years). Panel data on multiple age-related variables were used to estimate biological ages for each individual at each time point, in linear mixed effects models. A weighted average approach was used to combine variables within predefined body system groups. Aging trajectories for each system in each individual were then constructed using linear modeling. Multivariate structural equation modeling of these aging trajectories showed low genetic effects (heritability), ranging from 2% in metabolic aging to 22% in cardiovascular aging. However, we found a significant effect of shared environmental factors on the variations in aging trajectories in cardiovascular (54%), skeletal (34%), morphometric (53%), and metabolic...Continue Reading
References
Apr 1, 1987·Appetite·P Rozin, L Millman
Mar 1, 1968·Eugenics Quarterly·S Scarr
Jan 1, 1993·Behavior Genetics·K S KendlerL J Eaves
Apr 13, 1996·BMJ : British Medical Journal·T D SpectorD Hart
Jun 15, 2000·The New England Journal of Medicine·C J HammondC E Gilbert
Jul 13, 2000·The New England Journal of Medicine·P LichtensteinK Hemminki
Jan 10, 2002·Twin Research : the Official Journal of the International Society for Twin Studies·T AndrewA J MacGregor
Apr 3, 2002·Ophthalmology·Christopher J HammondTim D Spector
Sep 14, 2002·Experimental Aging Research·Matt McGue, Kaare Christensen
Jan 24, 2003·International Journal of Epidemiology·D J P BarkerC Osmond
Oct 24, 2003·Behavior Genetics·Deborah FinkelMagnus Svartengren
Nov 3, 2004·BMC Cardiovascular Disorders·Frances M K WilliamsAlex J MacGregor
Mar 25, 2005·Physiological Reviews·I Caroline McMillen, Jeffrey S Robinson
Sep 15, 2005·Archives of Internal Medicine·Karl MichaëlssonNancy L Pedersen
Oct 22, 2005·The British Journal of Educational Psychology·Ken Richardson, Sarah Norgate
Feb 8, 2006·Archives of General Psychiatry·Margaret GatzNancy L Pedersen
May 12, 2006·Journal of the American Geriatrics Society·Satu PajalaTaina Rantanen
Oct 2, 2007·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Peter V Tishler, Vincent J Carey
Feb 5, 2008·The Journal of Experimental Biology·Günter VogtChristoph D Schubart
Feb 29, 2008·American Journal of Human Genetics·Carl E G BruderJan P Dumanski
Mar 18, 2009·Psychology and Aging·Wendy JohnsonKaare Christensen
Apr 28, 2010·PloS One·Abigail FisherJane Wardle
May 14, 2011·Age·Serena DatoGiuseppe Passarino
Jul 25, 2012·Age and Ageing·Claire Joanne StevesStephen H D Jackson
Aug 1, 2012·Nature Reviews. Genetics·Jenny van DongenDorret I Boomsma
Oct 24, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Alireza MoayyeriTimothy D Spector
Aug 31, 2013·Behavior Genetics·Claire J StevesTim D Spector
Jan 9, 2014·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Deborah FinkelNancy L Pedersen