Agitation of the syringe and release of silicone oil.

Eye
Celso de Souza Dias JuniorGustavo Barreto Melo

Abstract

To investigate whether agitation promotes the release of silicone oil by different models of syringe used for intravitreal injection. This lab study analyzed eight syringe models by light microscopy for the release of silicone oil under agitation (flick), without agitation, and positive controls. Fourier-Transform Infrared Spectroscopy (FTIR) was performed to identify the molecular compounds inside the syringes. A total of 240 syringes were analyzed. The presence of silicone oil droplets was observed in all positive controls. When agitated by flicking, 100% of the samples of the syringes disclosed silicone oil, except the BD Plastipak syringe, which presented 40% of positivity. Without agitation, a smaller percentage of samples with silicone oil was observed. Agitation by flicking had a 265-fold greater chance of presenting oil droplets when compared with the syringes without agitation. There was a statistically significant difference between the three conditions (P < 0.05). Analysis of the tip of the plunger rubber by FTIR indicated the presence of polysiloxane (silicone oil) in all models of syringe. Agitation of the syringe promotes the release of silicone oil. It is recommended to improve the technique of injection and the ...Continue Reading

References

Aug 14, 2008·Retina·Sophie J Bakri, Noha S Ekdawi
Apr 15, 2014·Journal of Pharmaceutical Sciences·Alana GerhardtTheodore W Randolph
Sep 27, 2014·Journal of Pharmaceutical Sciences·Elena KrayukhinaKiichi Fukui
Jan 16, 2015·JAMA Ophthalmology·Paul HahnPravin U Dugel
Jul 21, 2015·Journal of Pharmaceutical Sciences·Carly Fleagle ChisholmTheodore W Randolph
Sep 30, 2015·Journal of Ophthalmology·Vikas TahSaruban Pasu
Mar 17, 2017·Retinal Cases & Brief Reports·Robert L AveryGabriel M Gordon
Nov 21, 2017·International Journal of Dermatology·Carlos G WambierJuan M Piñeiro Maceira
Feb 3, 2018·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Andrzej GrzybowskiUNKNOWN Euretina Board
Apr 25, 2018·American Journal of Ophthalmology Case Reports·Jea H YuRon P Gallemore
Feb 15, 2019·Eye·Gustavo Barreto MeloMaurício Maia
Feb 23, 2019·International Journal of Retina and Vitreous·Gustavo Barreto MeloMaurício Maia
Mar 27, 2019·The British Journal of Ophthalmology·Gustavo Barreto MeloRubens Belfort
Aug 23, 2019·Arquivos brasileiros de oftalmologia·Lydianne Lumack do Monte AgraMaurício Maia

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Citations

Mar 10, 2021·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Lukas Bisorca-GassendorfAnnekatrin Rickmann
May 9, 2021·International Journal of Retina and Vitreous·William J AndersonGustavo Barreto Melo

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Methods Mentioned

BETA
infrared spectroscopy

Software Mentioned

STATA
BD Plastipak

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