Agmatine attenuates hyperactivity and weight loss associated with activity-based anorexia in female rats

Pharmacology, Biochemistry, and Behavior
Brijesh G TaksandeNandkishor R Kotagale

Abstract

Anorexia nervosa is a debilitating eating disorder characterized by hypophagia, body weight loss, amenorrhea and intense fear of weight gain. In present study, the effect of subchronic agmatine treatment on development of activity based anorexia (ABA) in female rats has been investigated. Animals were injected with saline or agmatine (10-40 mg/kg, ip) just before the onset of dark phase and shifted to experimental cage with wheel for ABA test for 10days. A pre-weighed quantity of food pellets (10g) was placed daily for a restricted period of only 2h (1700-1900h) and food intake was monitored (g) manually by weighing the leftover food. Rats restricted to ABA paradigm, showed greater wheel running, suppressed food consumption, disrupted estrous cycle and weight loss. On the other hand, subchronic agmatine (10-40mg/kg, ip, for 10days) treatment decreased wheel running activity, pronounced increased in food intake and restored body weights as compared to saline treated animals. Further, agmatine treatment decreased corticosterone levels in ABA rats, thereby stabilizing HPA axis in ABA rats. Subchronic agmatine treatment also prevented the disruptions of estrous cycle. Considering the common resistance of anorexia nervosa to current...Continue Reading

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Citations

Oct 22, 2016·Journal of Neurochemistry·Silvana GaetaniMaria Beatrice Passani
Nov 12, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Andiara E FreitasAna Lúcia S Rodrigues
Jun 6, 2019·Frontiers in Nutrition·Martha A Schalla, Andreas Stengel
May 30, 2019·Fish Physiology and Biochemistry·Liyuan LvShan He
Jul 28, 2017·The Biochemical Journal·Gregor Laube, Hans-Gert Bernstein
May 8, 2019·Neurotoxicology·Nandkishor Ramdas KotagaleNazma Najirahmad Inamdar
Oct 4, 2021·Journal of Eating Disorders·Sara SpadiniAntonio Malgaroli

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