Agmatine attenuates methamphetamine-induced conditioned place preference in rats

European Journal of Pharmacology
David A ThornJun-Xu Li

Abstract

The polyamine agmatine modulates a variety of behavioral effects including the abuse-related effects of opioids and has been proposed as a potential medication candidate for the treatment of opioid abuse. However, little is known of the effects of agmatine on the abuse-related effects of other drugs of abuse. This study examined the effects of agmatine on the rewarding effects of methamphetamine in rats using a conditioned place preference paradigm. Methamphetamine (0.1-1.0mg/kg) dose-dependently increased the time spent in methamphetamine-paired side (place preference). Agmatine, at doses that did not produce place preference or aversion (10-32mg/kg), significantly decreased the development of methamphetamine-induced place preference when agmatine was administered in combination with methamphetamine during place conditioning. Agmatine also significantly decreased the expression of methamphetamine-induced place preference when an acute injection of agmatine was given immediately before test session. These doses of agmatine do not alter the motor activity in rats, suggesting that the observed attenuation of methamphetamine-induced place preference was not due to general behavioral disruption. Together, these data suggests that a...Continue Reading

References

Apr 11, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·Y FengJ E Piletz
Mar 19, 2004·Annals of the New York Academy of Sciences·Sandra C Roerig
May 19, 2005·European Journal of Pharmacology·Xiao-Li WeiJin Li
Oct 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pouya Tahsili-FahadanAhmad Reza Dehpour
Mar 21, 2006·European Journal of Pharmacology·Kelley F Kitto, Carolyn A Fairbanks
Nov 18, 2006·European Journal of Pharmacology·Scott M RawlsJacob Zisk
Jul 3, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Xiao-Li WeiJin Li
Jul 27, 2007·Cellular and Molecular Neurobiology·Ning WuJin Li
Jul 29, 2008·European Journal of Pharmacology·Rui-Bin SuJin Li
Mar 31, 2009·Pharmacology, Biochemistry, and Behavior·Rui-Bin SuJin Li
Mar 5, 2011·European Journal of Pharmacology·Jun-Xu Li, Yanan Zhang
Apr 6, 2011·Behavioral Neuroscience·Robin M VoigtT Celeste Napier
Sep 7, 2011·Neuroscience and Biobehavioral Reviews·Tayfun I Uzbay
Nov 24, 2011·Neuroreport·Cristal SampsonJun-Xu Li

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Citations

Feb 22, 2014·Behavioural Pharmacology·Nobue KitanakaMotohiko Takemura
Mar 12, 2016·Drug Target Insights·Junichi KitanakaMotohiko Takemura
Apr 20, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David A ThornJun-Xu Li
Sep 26, 2015·Pharmacological Reviews·Esa R KorpiGavin S Dawe
Jul 28, 2017·The Biochemical Journal·Gregor Laube, Hans-Gert Bernstein
Jan 9, 2022·Naunyn-Schmiedeberg's Archives of Pharmacology·V ŞorodocO M Manole

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