PMID: 8971790Nov 22, 1996Paper

Agmatine does not have activity at alpha 2-adrenoceptors which modulate the firing rate of locus coeruleus neurones: an electrophysiological study in rat

Neuroscience Letters
J PinedaL Ugedo

Abstract

Agmatine (decarboxylated arginine) has been proposed as an endogenous ligand for non-adrenoceptor, imidazoline binding sites, but also binds to alpha 2-adrenoceptors. The interaction of agmatine with alpha 2-adrenoceptors was evaluated by studying the effect of agmatine on the firing rate of locus coeruleus (LC) neurones using extracellular recordings in anesthetized rats and rat brain slices. In vivo, local application of agmatine into the LC caused a slight and short-lasting increase in cell firing rate (P < 0.005). In vitro, agmatine failed to change the firing rate of LC neurones nor did it antagonize the inhibitory effect of noradrenaline on these cells. Since alpha 2-adrenoceptors are known to inhibit the firing of LC cells, we conclude that agmatine does not have agonist or antagonist properties at alpha 2-adrenoceptors of these neurones.

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Citations

Apr 2, 2008·Journal of Neural Transmission·Jarogniew J LuszczkiStanislaw J Czuczwar
Apr 8, 1999·European Journal of Pharmacology·G HorváthG Benedek
Aug 9, 2003·Neuropharmacology·Shadpour DemehriAhmad Reza Dehpour
Mar 6, 2002·British Journal of Pharmacology·Eduardo Ruiz-DurántezLuisa Ugedo
Oct 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pouya Tahsili-FahadanAhmad Reza Dehpour
Feb 24, 2004·Cardiovascular Drug Reviews·Reinhard BerkelsEdgar Schömig

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