Agmatine produces antidepressant-like effects in two models of depression in mice

Neuroreport
Andréa D E ZomkowskiAna Lúcia S Rodrigues

Abstract

Agmatine produces an antidepressant-like effect when assessed in the forced swimming test (FST) and in the tail suspension test (TST) in mice (dose range 0.01-50 mg/kg, i.p.), without accompanying changes in ambulation in an open-field. I.c.v. injection of agmatine (1-100 nmol/site) also reduced the immobility time in the FST. Agmatine significantly enhanced the anti-immobility effect of imipramine, but did not affect that of MK-801. The anti-immobility effect of agmatine assessed in the FST was not affected by pre-treatment with prazosin. In contrast, agmatine's antidepressant-like effect was completely prevented by pre-treatment of animals with yohimbine, GMP or L-arginine. Taken together these data demonstrate that agmatine elicited a significant antidepressant-like effect through a mechanism that seems to involve an interaction with NMDA receptors, the L-arginine-nitric oxide pathway and alpha2-adrenoceptors.

References

Apr 1, 1991·Trends in Pharmacological Sciences·P Willner
Jan 1, 1984·Annual Review of Biochemistry·C W Tabor, H Tabor
Sep 1, 1996·Pharmacology & Toxicology·A L RodriguesD O Souza
Jan 14, 1998·Neuroreport·A RegnerD Souza
Jul 23, 1999·Annals of the New York Academy of Sciences·D J Reis, S Regunathan
Jul 23, 1999·Annals of the New York Academy of Sciences·A HalarisJ E Piletz
Aug 12, 1999·European Journal of Pharmacology·P Skolnick
Apr 13, 2000·Brain Research. Brain Research Reviews·A Contestabile
Apr 29, 2000·Trends in Pharmacological Sciences·D J Reis, S Regunathan
May 4, 2000·Brain Research·A P SchmidtD Onofre Souza
Jul 7, 2000·Neuroreport·A L EckeliA L Rodrigues
Mar 30, 2001·Nature·F Vollrath, D P Knight
May 1, 2001·Nature Medicine·H K ManjiD S Charney
May 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·O Yeşilyurt, I T Uzbay
Jun 23, 2001·Pharmacology, Biochemistry, and Behavior·A Onal, N Soykan
Jul 17, 2001·British Journal of Pharmacology·W RaaschP Dominiak

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Citations

Apr 2, 2008·Journal of Neural Transmission·Jarogniew J LuszczkiStanislaw J Czuczwar
Jan 22, 2013·Neurotoxicity Research·John E PiletzFeng Yangzheng
Nov 5, 2013·European Journal of Pharmacology·Brijesh G TaksandeNandkishor R Kotagale
Jun 7, 2005·Physiology & Behavior·Feyza Aricioglu, Soundar Regunathan
Jul 26, 2002·Life Sciences·Feyza Aricioglu-Kartal, Soundar Regunathan
Aug 9, 2003·Neuropharmacology·Shadpour DemehriAhmad Reza Dehpour
Apr 4, 2003·Behavioural Brain Research·Daniel LavinskyCarlos Alexandre Netto
Aug 30, 2003·Behavioural Brain Research·Angelo Oscar RosaAna Lúcia S Rodrigues
Oct 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pouya Tahsili-FahadanAhmad Reza Dehpour
Aug 24, 2013·Biological & Pharmaceutical Bulletin·Seungheon LeeJi Wook Jung
Feb 5, 2014·Translational Stroke Research·Yi Ping ZhangChristopher B Shields
Aug 28, 2014·Journal of Psychiatric Research·Andiara E FreitasAna Lúcia S Rodrigues
Jan 3, 2015·Pharmacology, Biochemistry, and Behavior·Vivian Binder NeisAna Lúcia S Rodrigues
Jun 19, 2013·Drug Discovery Today·John E PiletzGad M Gilad
Sep 22, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Leandro C SouzaCristiano R Jesse
Jan 4, 2012·Pharmacology & Therapeutics·Gerhard J Molderings, Britta Haenisch
May 17, 2011·Pharmacology, Biochemistry, and Behavior·Carlos Riaza Bermudo-SorianoEnrique Baca-Garcia
Mar 29, 2011·European Journal of Pharmacology·Onder OzdenTayfun Uzbay
Nov 26, 2015·European Journal of Pharmacology·Nitin B GawaliArchana R Juvekar
Jul 20, 2010·Journal of Ethnopharmacology·Seungjoo LeeJong Hoon Ryu
Jun 18, 2010·Neuroscience Letters·Maarja KrassVallo Volke
Apr 17, 2010·European Journal of Pharmacology·Brijesh G TaksandeChandrabhan T Chopde
Jan 28, 2010·Life Sciences·Cristiani F BortolattoCristina W Nogueira
Dec 8, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cristiano R JesseCristina W Nogueira
May 15, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ricardo W BinfaréAna Lúcia S Rodrigues
Dec 25, 2008·European Journal of Pharmacology·Takahiro SugiuraYasuo Matsumura
Dec 9, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chandra C CardosoAna Lúcia S Rodrigues
Dec 8, 2015·Canadian Journal of Physiology and Pharmacology·Dalia H El-KashefHatem A Salem
Jun 25, 2008·European Journal of Pharmacology·Erik PålssonDaniel Klamer
Apr 21, 2007·European Journal of Pharmacology·Mariana P ZeidanNelson H Gabilan
Apr 17, 2007·European Journal of Pharmacology·Manuella Pinto KasterAna Lúcia S Rodrigues
Aug 23, 2011·Fundamental & Clinical Pharmacology·Caroline Porto Leite TeixeiraFrancisca Cléa Florenço de Sousa

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