Agomelatine, venlafaxine, and running exercise effectively prevent anxiety- and depression-like behaviors and memory impairment in restraint stressed rats

PloS One
Sarawut LapmaneeNarattaphol Charoenphandhu

Abstract

Several severe stressful situations, e.g., natural disaster, infectious disease out break, and mass casualty, are known to cause anxiety, depression and cognitive impairment, and preventive intervention for these stress complications is worth exploring. We have previously reported that the serotonin-norepinephrine-dopamine reuptake inhibitor, venlafaxine, as well as voluntary wheel running are effective in the treatment of anxiety- and depression-like behaviors in stressed rats. But whether they are able to prevent deleterious consequences of restraint stress in rats, such as anxiety/depression-like behaviors and memory impairment that occur afterward, was not known. Herein, male Wistar rats were pre-treated for 4 weeks with anti-anxiety/anti-depressive drugs, agomelatine and venlafaxine, or voluntary wheel running, followed by 4 weeks of restraint-induced stress. During the stress period, rats received neither drug nor exercise intervention. Our results showed that restraint stress induced mixed anxiety- and depression-like behaviors, and memory impairment as determined by elevated plus-maze, elevated T-maze, open field test (OFT), forced swimming test (FST), and Morris water maze (MWM). Both pharmacological pre-treatments and...Continue Reading

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Citations

Aug 30, 2018·International Journal of Geriatric Psychiatry·Nicola VeronesePinar Soysal
Sep 12, 2018·The Journal of Physiological Sciences : JPS·Paul D Loprinzi, Emily Frith
Dec 5, 2018·Neurology Research International·Jegan Sakthivel NadarRuchita Dhangar
Apr 8, 2021·Biological Trace Element Research·Qiqi CaoZilong Sun
Apr 6, 2021·Frontiers in Behavioral Neuroscience·Lidong SunShangwu Jin
Sep 18, 2021·ACS Medicinal Chemistry Letters·Onrapak ReamtongSomsak Ruchirawat

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Methods Mentioned

BETA
electrophoresis
Protein Assay

Software Mentioned

GraphPad Prism
GraphPad

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