Agonist-Biased Signaling via Matrix Metalloproteinase-9 Promotes Extracellular Matrix Remodeling

Cells
Bessi QorriMyron R Szewczuk

Abstract

The extracellular matrix (ECM) is a highly dynamic noncellular structure that is crucial for maintaining tissue architecture and homeostasis. The dynamic nature of the ECM undergoes constant remodeling in response to stressors, tissue needs, and biochemical signals that is are mediated primarily by matrix metalloproteinases (MMPs), which work to degrade and build up the ECM. Research on MMP-9 has demonstrated that this proteinase exists on the cell surface of many cell types in complex with G protein-coupled receptors (GPCRs), and receptor tyrosine kinases (RTKs) or Toll-like receptors (TLRs). Through a novel yet ubiquitous signaling platform, MMP-9 is found to play a crucial role not only in the direct remodeling of the ECM but also in the transactivation of associated receptors to mediate and recruit additional remodeling proteins. Here, we summarize the role of MMP-9 as it exists in a tripartite complex on the cell surface and discuss how its association with each of the TrkA receptor, Toll-like receptors, epidermal growth factor receptor, and the insulin receptor contributes to various aspects of ECM remodeling.

References

Nov 21, 1986·Cell·D JohnsonM Chao
Jan 1, 1995·Annual Review of Neuroscience·M Bothwell
Jan 12, 1996·The Journal of Biological Chemistry·K BaltenspergerC C Malbon
May 1, 1997·The American Journal of Physiology·C A PartridgeJ J Jeffrey
Nov 18, 1997·Cell·R Medzhitov, C A Janeway
Aug 19, 2000·Cellular and Molecular Life Sciences : CMLS·J Ivaska, J Heino
Oct 6, 2000·The American Journal of Pathology·S WangR Kraemer
Dec 20, 2000·Experimental Cell Research·A PuyraimondS Menashi
Jan 21, 2001·The Journal of Biological Chemistry·Y OkamuraJ F Strauss
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·F S Lee, M V Chao
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·L CalzaR Levi-Montalcini
May 7, 2002·Nature Reviews. Cancer·Mikala Egeblad, Zena Werb
Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Giuseppina CantarellaRenato Bernardini
Oct 23, 2002·Circulation·Costanza EmanueliPaolo Madeddu
Jun 6, 2003·Cancer Metastasis Reviews·Rafael FridmanShahriar Mobashery
Jul 8, 2003·The Journal of Pathology·Ivan Stamenkovic
Sep 6, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Rosemary Kraemer, Barbara L Hempstead
Nov 20, 2003·Journal of Cell Science·Wesley K KroezeBryan L Roth
Dec 4, 2003·Biochemical Society Transactions·N J PyneS Pyne
Apr 22, 2004·The Journal of Allergy and Clinical Immunology·Peter R A JohnsonJudith L Black
Jul 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rithwick RajagopalMoses V Chao

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Citations

Dec 25, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mythili DileepanSavita P Rao
Oct 8, 2020·International Journal of Molecular Sciences·Marta KollarovaJana Radosinska
Oct 23, 2020·Advanced Drug Delivery Reviews·Xin DingPeiyan Yuan
May 1, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yunsen ZhangYi Zhang
Sep 10, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu-Bei JinChun-Feng Wang

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Methods Mentioned

BETA
xenografts
xenograft
glycosylation

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Cell Signaling by Tyrosine Kinases

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