PMID: 9448940Feb 4, 1998Paper

Agonist mobilization of sarcoplasmic reticular calcium in smooth muscle: functional coupling to the plasmalemmal Na+/Ca2+ exchanger?

Cell Calcium
M J Taggart, S Wray

Abstract

There is a close association of peripheral sarcoplasmic reticulum (SR), containing IP3 receptors, and regions of the plasma membrane enriched in the Na+/Ca2+ exchanger in smooth muscle. We have tested the possibility in rat uterine smooth muscle that Ca2+ released from the SR is preferentially removed from the cytosol by the Na+/Ca2+ exchanger. In Ca(2+)-free solution, carbachol stimulation of myometria of non-pregnant rats resulted in transient increases in [Ca2+]i and force due entirely to the release of SR Ca2+. Inhibition of Na+/Ca2+ exchange by removal of extracellular Na+ did not alter the agonist-induced transients suggesting that Na+/Ca2+ exchange was not involved in the removal of SR released Ca2+. However, in myometria of pregnant rats, Na+/Ca2+ exchange inhibition resulted in changes in the agonist-induced [Ca2+]i transient profiles. The peak amplitude, duration and integral of carbachol-induced [Ca+]i transients were enhanced in Ca(2+)-free/Na(+)-free solution without significantly affecting force transients. The lower rate of decay of [Ca2+]i transients in Na(+)-free solution leads us to suggest that up to 35% of the SR released Ca2+ may be extruded by the Na+/Ca2+ exchanger in myometria of pregnant rats. Thus, in ...Continue Reading

References

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Citations

Apr 28, 2004·Cell Calcium·Anatoly Shmygol, Susan Wray
Jan 16, 2004·Trends in Pharmacological Sciences·Damon PoburkoCornelis van Breemen
Nov 16, 2002·European Journal of Pharmacology·Keerai T AsokanVellanki Raviprakash
Jun 17, 2010·Human Reproduction Update·Hector N Aguilar, B F Mitchell
Mar 17, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Karen NobleSusan Wray
Mar 3, 2007·Annals of the New York Academy of Sciences·Anatoly ShmygolSteven Thornton
Feb 17, 2007·Annals of the New York Academy of Sciences·Theodor BurdygaKaren Noble
Jul 5, 2008·Journal of Molecular and Cellular Cardiology·Brian Oloizia, Richard J Paul
Jul 13, 2007·Cell Calcium·Rachel Floyd, Susan Wray
Aug 23, 2000·Biology of Reproduction·R M TribeL Poston
Jul 3, 2007·Seminars in Cell & Developmental Biology·Susan Wray, Anatoly Shmygol
May 4, 2004·Journal of the Society for Gynecologic Investigation·A MatthewS Wray
Jan 24, 2002·The Journal of Continuing Education in the Health Professions·P A Lombardo
Apr 5, 2001·American Journal of Physiology. Cell Physiology·C Wu, C H Fry

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