PMID: 8955559Nov 1, 1996Paper

Agonist-stimulated calcium transients in PC12 cells are affected differentially by cadmium and nickel

Cell Calcium
J BentersS Hechtenberg

Abstract

Rat pheochromocytoma (PC12) cells were loaded with the fluorescent indicator Fura-2 and the effects of cadmium and nickel on the mobilization of calcium elicited by bradykinin and external ATP were studied. Cadmium and nickel ions provoked a concentration-dependent decrease of the initial peak and/or the subsequent plateau phase of bradykinin-induced Ca2+ transients in a different manner: whereas cadmium (0.5-2.5 microM) diminished the calcium peak without modifying the sustained plateau, nickel (25-1000 microM) only slightly lowered the peak but markedly decreased the plateau phase. In the case of ATP-stimulated calcium transients, which are without a sustained plateau, both cadmium and nickel ions decreased the peak signal. Possible consequences are discussed in terms of a disturbance of hormone-stimulated cell activation by cadmium and nickel.

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Citations

Jun 8, 2002·Toxicology Letters·Detmar Beyersmann
Sep 17, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Carla Marchetti
Nov 4, 2008·Brain Research Bulletin·T Leon LassiterTheodore A Slotkin
May 2, 2012·Neurotoxicology and Teratology·Theodore A Slotkin, Frederic J Seidler
Apr 4, 2006·The Journal of Eukaryotic Microbiology·Hongwei Ma, Robin M Overstreet

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