Agonistic and antagonistic actions of 3,4-dihydroxy-substituted phenoxypropanolamines in guinea-pig atria and trachea

Clinical and Experimental Pharmacology & Physiology
G S KehH Dowd

Abstract

1. Racemic mixtures of noradrenaline, adrenaline, isoprenaline, N-t-butylnor-adrenaline and their corresponding derivatives containing an oxymethylene (OM) link between the phenyl ring and ethanolamine side-chain have been tested for their effects on beta-adrenoceptors in isolated guinea-pig atrial and tracheal preparations. 2. In atrial and in spontaneously contracted tracheal preparations both the parent catecholamines and their corresponding OM-derivatives had a similar order of potency as beta-receptor agonists. 3. In carbachol-stimulated tracheal preparations the OM-derivatives were shown to have partial agonistic actions. 4. As in other phenylethanolamines and phenoxypropanolamines, both the agonistic and antagonistic potency of the OM-derivatives increased with increasing amine substitution.

References

Apr 1, 1976·The Journal of Pharmacy and Pharmacology·W C Bowman, C Raper
Jul 1, 1977·Clinical and Experimental Pharmacology & Physiology·K Bohmer, C Raper
Feb 1, 1975·Journal of Medicinal Chemistry·C F SchwenderJ Shavel
Apr 1, 1975·Pharmacological Research Communications·A C Dreyer, J Offermeier
Mar 1, 1973·European Journal of Pharmacology·E J Mylecharane, C Raper
Aug 1, 1973·The Journal of Pharmacy and Pharmacology·C Raper, E Malta
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD

Related Concepts

Airway Resistance
Metazoa
Carboptic
Epinephrine Acetate
Cavia porcellus
Novodrin
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Norepinephrine, (+, -)-Isomer
Propanolamines
Trachea

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